Oculomotor Deficits after Chemotherapy in Childhood

Article


Rota, Rossella, Einarsson, Einar-Jón, Patel, M., Petersen, Hannes, Wiebe, Thomas, Magnusson, Måns, Moëll, Christian and Fransson, Per-Anders 2016. Oculomotor Deficits after Chemotherapy in Childhood. PLOS ONE. 11 (1), p. e0147703.
AuthorsRota, Rossella, Einarsson, Einar-Jón, Patel, M., Petersen, Hannes, Wiebe, Thomas, Magnusson, Måns, Moëll, Christian and Fransson, Per-Anders
Abstract

Advances in the diagnosis and treatment of pediatric malignancies have substantially
increased the number of childhood cancer survivors. However, reports suggest that some
of the chemotherapy agents used for treatment can cross the blood brain barrier which may
lead to a host of neurological symptoms including oculomotor dysfunction. Whether chemotherapy
at young age causes oculomotor dysfunction later in life is unknown. Oculomotor
performance was assessed with traditional and novel methods in 23 adults (mean age 25.3
years, treatment age 10.2 years) treated with chemotherapy for a solid malignant tumor not
affecting the central nervous system. Their results were compared to those from 25 healthy,
age-matched controls (mean age 25.1 years). Correlation analysis was performed between
the subjective symptoms reported by the chemotherapy treated subjects (CTS) and oculomotor
performance. In CTS, the temporal control of the smooth pursuit velocity (velocity
accuracy) was markedly poorer (p<0.001) and the saccades had disproportionally shorter
amplitude than normal for the associated saccade peak velocity (main sequence) (p =
0.004), whereas smooth pursuit and saccade onset times were shorter (p = 0.004) in CTS
compared with controls. The CTS treated before 12 years of age manifested more severe
oculomotor deficits. CTS frequently reported subjective symptoms of visual disturbances
(70%), unsteadiness, light-headedness and that things around them were spinning or moving
(87%). Several subjective symptoms were significantly related to deficits in oculomotor
performance. To conclude, chemotherapy in childhood or adolescence can result in severe
oculomotor dysfunctions in adulthood. The revealed oculomotor dysfunctions were significantly
related to the subjects’ self-perception of visual disturbances, dizziness, light-headedness
and sensing unsteadiness. Assessments of oculomotor function may, thus, offer an
objective method to track and rate the level of neurological complications following
chemotherapy.

JournalPLOS ONE
Journal citation11 (1), p. e0147703
ISSN1932-6203
Year2016
PublisherPublic Library of Science
Publisher's version
License
CC BY
Digital Object Identifier (DOI)doi:10.1371/journal.pone.0147703
Publication dates
Print27 Jan 2016
Publication process dates
Deposited29 Jan 2016
Accepted07 Jan 2016
Copyright information© 2016 The authors
Permalink -

https://repository.uel.ac.uk/item/8528q

  • 8
    total views
  • 51
    total downloads
  • 2
    views this month
  • 4
    downloads this month

Related outputs

Psychological Assessment and Documentation of Torture in Detention
Patel, M. 2017. Psychological Assessment and Documentation of Torture in Detention. in: Payne-James, Jason, Beynon, Jonathan and Vieira, Duarte (ed.) Monitoring Detention, Custody, Torture and Ill-treatment: A Practical Approach to Prevention and Documentation CRC Press: Taylor & Francis Group.
Vestibular and oculomotor influences on visual dependency
Roberts, R. Edward, Da Silva Melo, Mariane, Siddiqui, Aazim A, Arshad, Qadeer and Patel, M. 2016. Vestibular and oculomotor influences on visual dependency. Journal of Neurophysiology. 116 (3), pp. 1480-1487.
Acute alcohol intoxication impairs segmental body alignment in upright standing
Hafstrom, A, Patel, M., Modig, F, Magnusson, M and Fransson, Per-Anders 2014. Acute alcohol intoxication impairs segmental body alignment in upright standing. Journal of Vestibular Research. 24 (4), pp. 297-304.
Applications of neuromodulation to explore vestibular cortical processing; new insights into the effects of direct current cortical modulation upon pursuit, VOR and VOR suppression
Ahmad, H, Arshad, Qadeer, Siddiqui, S, Nigmatullina, Y., Patel, M., Bronstein, A. M. and Roberts, R. E. 2014. Applications of neuromodulation to explore vestibular cortical processing; new insights into the effects of direct current cortical modulation upon pursuit, VOR and VOR suppression. Journal of Vestibular Research. 24 (5-6), pp. 453-458.
Decreased postural control in adolescents born with extremely low birth weight
Petersen, Hannes, Tulinius, Arnar-Thor, Georgsdóttir, Ingibjörg, Einarsson, Einar-Jon, Patel, M., Haraldsson, Ásgeir and Fransson, Per-Anders 2015. Decreased postural control in adolescents born with extremely low birth weight. Experimental Brain Research. 233 (5), pp. 1651-1662.
Using Transcranial Magnetic Stimulation (TMS) to Probe Effects of Visual Motion Adaptation on Primary Visual Cortex (V1) Excitability in Bilateral Vestibular Failure (BVF) Patients
Ahmad, Hena, Roberts, Richard, Arshad, Qadeer Arshad, Patel, M. and Bronstein, Adolfo 2015. Using Transcranial Magnetic Stimulation (TMS) to Probe Effects of Visual Motion Adaptation on Primary Visual Cortex (V1) Excitability in Bilateral Vestibular Failure (BVF) Patients. Journal of Neurology, Neurosurgery & Psychiatry. 86 (11), pp. e4.70-e4.
Acquired Pendular Nystagmus in Stargardt's Syndrome Suppressed by Alcohol
Ahmad, Hena, Arshad, Qadeer, Patel, M., Roberts, Richard and Bronstein, Adolfo 2015. Acquired Pendular Nystagmus in Stargardt's Syndrome Suppressed by Alcohol. Journal of Neurology, Neurosurgery & Psychiatry. 86 (11), pp. e4.120-e4.
Effects of Prochlorperazine on Normal Vestibular Ocular and Perceptual Responses: A Randomised, Double-Blind, Crossover, Placebo-Controlled Study
Patel, M., Nigmatullina, Y., Seemungal, B.M., Golding, J.F. and Bronstein, A.M. 2013. Effects of Prochlorperazine on Normal Vestibular Ocular and Perceptual Responses: A Randomised, Double-Blind, Crossover, Placebo-Controlled Study. Audiology and Neurotology. 19 (2), pp. 91-96.
Attention modulates adaptive motor learning in the ‘broken escalator’ paradigm
Patel, M., Kaski, Diego and Bronstein, Adolfo M. 2014. Attention modulates adaptive motor learning in the ‘broken escalator’ paradigm. Experimental Brain Research. 232 (7), pp. 2349-2357.
Does outstretching the arms improve postural stability?
Patel, M., Buckwell, David, Hawken, Malcolm and Bronstein, Adolfo M. 2014. Does outstretching the arms improve postural stability? Neuroscience Letters. 579, pp. 97-100.
Long-Term Effects from Bacterial Meningitis in Childhood and Adolescence on Postural Control
Lidzba, Karen, Petersen, Hannes, Patel, M., Ingason, Einar F., Einarsson, Einar J., Haraldsson, Ásgeir and Fransson, Per-Anders 2014. Long-Term Effects from Bacterial Meningitis in Childhood and Adolescence on Postural Control. PLOS ONE. 9 (11), p. e112016.
A brief review of the clinical anatomy of the vestibular-ocular connections—how much do we know?
Bronstein, A M, Patel, M. and Arshad, Q 2015. A brief review of the clinical anatomy of the vestibular-ocular connections—how much do we know? Eye. 29 (2), pp. 163-170.
Role of handedness-related vestibular cortical dominance upon the vestibular–ocular reflex
Arshad, Q., Patel, M., Goga, U., Nigmatullina, Y. and Bronstein, A. M. 2015. Role of handedness-related vestibular cortical dominance upon the vestibular–ocular reflex. Journal of Neurology. 262 (4), pp. 1069-1071.
Peripheral Vestibular Dysfunction in Patients With Primary Ciliary Dyskinesia
Rimmer, Joanne, Patel, M., Agarwal, Kiran, Hogg, Claire, Arshad, Qadeer and Harcourt, Jonny 2015. Peripheral Vestibular Dysfunction in Patients With Primary Ciliary Dyskinesia. Otology and Neurotology. 36 (4), pp. 662-669.
Galvanic Vestibular Stimulation Induces a Spatial Bias in Whole-body Position Estimates
Patel, M., Roberts, R. Edward, Arshad, Qadeer, Ahmed, Maroof, Riyaz, Mohammed U. and Bronstein, Adolfo M. 2015. Galvanic Vestibular Stimulation Induces a Spatial Bias in Whole-body Position Estimates. Brain Stimulation. 8 (5), pp. 981-983.
Locomotor adaptation is modulated by observing the actions of others
Patel, M., Roberts, R. Edward, Riyaz, Mohammed U., Ahmed, Maroof, Buckwell, David, Bunday, Karen, Ahmad, Hena, Kaski, Diego, Arshad, Qadeer and Bronstein, Adolfo M. 2015. Locomotor adaptation is modulated by observing the actions of others. Journal of Neurophysiology. 114 (3), pp. 1538-1544.
Chronic symptoms after vestibular neuritis and the high velocity vestibulo-ocular reflex
Patel, M., Arshad, Qadeer, Roberts, R. Edward, Ahmad, Hena and Bronstein, Adolfo M. 2016. Chronic symptoms after vestibular neuritis and the high velocity vestibulo-ocular reflex. Otology and Neurotology. 37 (2), pp. 179-184.