Long-Term Effects from Bacterial Meningitis in Childhood and Adolescence on Postural Control

Article


Lidzba, Karen, Petersen, Hannes, Patel, M., Ingason, Einar F., Einarsson, Einar J., Haraldsson, Ásgeir and Fransson, Per-Anders 2014. Long-Term Effects from Bacterial Meningitis in Childhood and Adolescence on Postural Control. PLOS ONE. 9 (11), p. e112016.
AuthorsLidzba, Karen, Petersen, Hannes, Patel, M., Ingason, Einar F., Einarsson, Einar J., Haraldsson, Ásgeir and Fransson, Per-Anders
Abstract

Bacterial meningitis in childhood is associated with cognitive deficiencies, sensorimotor impairments and motor dysfunction
later in life. However, the long-term effects on postural control is largely unknown, e.g., whether meningitis subjects as
adults fully can utilize visual information and adaptation to enhance stability. Thirty-six subjects (20 women, mean age 19.3
years) treated in childhood or adolescence for bacterial meningitis, and 25 controls (13 women, mean age 25.1 years)
performed posturography with eyes open and closed under unperturbed and perturbed standing. The meningitis subjects
were screened for subjective vertigo symptoms using a questionnaire, clinically tested with headshake and head thrust test,
as well as their hearing was evaluated. Meningitis subjects were significantly more unstable than controls during
unperturbed (p#0.014) and perturbed standing, though while perturbed only with eyes open in anteroposterior direction
(p = 0.034) whereas in lateral direction both with eyes open and closed (p,0.001). Meningitis subjects had poorer adaption
ability to balance perturbations especially with eyes open, and they frequently reported symptoms of unsteadiness (88% of
the subjects) and dizziness (81%), which was found significantly correlated to objectively decreased stability. Out of the 36
subjects only 3 had unilateral hearing impairment. Hence, survivors of childhood bacterial meningitis may suffer long-term
disorders affecting postural control, and would greatly benefit if these common late effects became generally known so
treatments can be developed and applied.

JournalPLOS ONE
Journal citation9 (11), p. e112016
ISSN1932-6203
Year2014
PublisherPublic Library of Science
Publisher's version
License
CC BY
Web address (URL)http://dx.doi.org/10.1371/journal.pone.0112016
Publication dates
Print18 Nov 2014
Publication process dates
Deposited25 Nov 2015
Accepted12 Oct 2014
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https://repository.uel.ac.uk/item/85850

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