Effects of Prochlorperazine on Normal Vestibular Ocular and Perceptual Responses: A Randomised, Double-Blind, Crossover, Placebo-Controlled Study

Article


Patel, M., Nigmatullina, Y., Seemungal, B.M., Golding, J.F. and Bronstein, A.M. 2013. Effects of Prochlorperazine on Normal Vestibular Ocular and Perceptual Responses: A Randomised, Double-Blind, Crossover, Placebo-Controlled Study. Audiology and Neurotology. 19 (2), pp. 91-96.
AuthorsPatel, M., Nigmatullina, Y., Seemungal, B.M., Golding, J.F. and Bronstein, A.M.
Abstract

Background: The present study investigated whether prochlorperazine affects
vestibular-ocular reflex (VOR) and vestibulo-perceptual function. Methods: We
studied 12 healthy naïve subjects 3 hours after a single dose of oral prochlorperazine
5mg in a randomised, placebo-controlled, double-blind, cross-over study in healthy
young subjects. Two rotational tests in yaw were used: 1) a Threshold task
investigating perceptual motion detection and nystagmic thresholds (acceleration
steps of 0.5deg/s/s) and 2) Suprathreshold responses to velocity steps of 90deg/s in
which vestibulo-ocular (VO) and vestibulo-perceptual (VP) time constants of decay,
as well as VOR gain, were measured. Results: Prochlorperazine had no effect upon
any measure of nystagmic or perceptual vestibular function compared to placebo. This
lack of effects on vestibular-mediated motion perception suggests that the drug is
likely to act more as an antiemetic than as an anti-vertiginous agent.

JournalAudiology and Neurotology
Journal citation19 (2), pp. 91-96
ISSN1421-9700
1420-3030
Year2013
PublisherKarger
Accepted author manuscript
License
CC BY
Web address (URL)http://dx.doi.org/10.1159/000357028
Publication dates
Print21 Dec 2013
Publication process dates
Deposited25 Nov 2015
Accepted20 Oct 2013
FunderMedical Research Council
Meniere’s Society
Copyright information© 2013 Karger
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