Development of Purine-Derived18F-Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET
Article
Galante, E., Okamura, Toshimitsu, Sande, Kerstin, Kikuchi, Tatsuya, Okada, Maki, Zhang, Ming-Rong, Robson, Mathew, Badar, Adam, Lythgoe, Mark, Koepp, Matthias and Årstad, Erik 2014. Development of Purine-Derived18F-Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET. Journal of Medicinal Chemistry. 57 (3), pp. 1023-1032. https://doi.org/10.1021/jm401764a
Authors | Galante, E., Okamura, Toshimitsu, Sande, Kerstin, Kikuchi, Tatsuya, Okada, Maki, Zhang, Ming-Rong, Robson, Mathew, Badar, Adam, Lythgoe, Mark, Koepp, Matthias and Årstad, Erik |
---|---|
Abstract | Multidrug resistance-associated protein 1 (MRP1) is a drug efflux transporter that has been implicated in the pathology of several neurological diseases and is associated with development of multidrug resistance. To enable measurement of MRP1 function in the living brain, a series of 6-halopurines decorated with fluorinated side chains have been synthesized and evaluated as putative pro-drug tracers. The tracers were designed to undergo conjugation with glutathione within the brain and hence form the corresponding MRP1 substrate tracers in situ. |
Journal | Journal of Medicinal Chemistry |
Journal citation | 57 (3), pp. 1023-1032 |
ISSN | 0022-2623 |
Year | 2014 |
Publisher | American Chemical Society (ACS) |
Digital Object Identifier (DOI) | https://doi.org/10.1021/jm401764a |
Web address (URL) | https://doi.org/10.1021/jm401764a |
Publication dates | |
23 Jan 2014 | |
Publication process dates | |
Deposited | 18 Aug 2017 |
Accepted | 01 Jan 2014 |
Copyright information | © 2014 American Chemical Society |
https://repository.uel.ac.uk/item/85qx3
162
total views0
total downloads1
views this month0
downloads this month