Synthesis of water-soluble nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity
Consoli, Grazia M.L., Granata, Giuseppe, Galante, E., Di Silvestro, Isabella, Salafia, Laura and Geraci, Corrada 2007. Synthesis of water-soluble nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity. Tetrahedron. 63 (44), pp. 10758-10763.
|Authors||Consoli, Grazia M.L., Granata, Giuseppe, Galante, E., Di Silvestro, Isabella, Salafia, Laura and Geraci, Corrada|
Calixarenes bearing four thymine or adenine 2′-deoxynucleotide moieties have been synthesized and characterized by NMR and ESI-MS analysis. Due to their amphiphilic nature, the conjugates (2a and 2b) obtained tend to self-assemble in aqueous medium by stacking interactions. Their good water solubility makes 2a and 2b promising candidates for bioorganic applications. A preliminary study has provided evidence of their inhibitory activity toward the replication of a Penicillium digitatum DNA fragment via PCR (polymerase chain reaction).
|Journal citation||63 (44), pp. 10758-10763|
|Digital Object Identifier (DOI)||doi:10.1016/j.tet.2007.06.123|
|Web address (URL)||https://doi.org/10.1016/j.tet.2007.06.123|
|29 Oct 2007|
|Publication process dates|
|Deposited||18 Aug 2017|
|Accepted||05 Jun 2007|
|Copyright information||© Elsevier 2007|
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