Synthesis of water-soluble nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity

Article


Consoli, Grazia M.L., Granata, Giuseppe, Galante, E., Di Silvestro, Isabella, Salafia, Laura and Geraci, Corrada 2007. Synthesis of water-soluble nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity. Tetrahedron. 63 (44), pp. 10758-10763.
AuthorsConsoli, Grazia M.L., Granata, Giuseppe, Galante, E., Di Silvestro, Isabella, Salafia, Laura and Geraci, Corrada
Abstract

Calix[4]arenes bearing four thymine or adenine 2′-deoxynucleotide moieties have been synthesized and characterized by NMR and ESI-MS analysis. Due to their amphiphilic nature, the conjugates (2a and 2b) obtained tend to self-assemble in aqueous medium by stacking interactions. Their good water solubility makes 2a and 2b promising candidates for bioorganic applications. A preliminary study has provided evidence of their inhibitory activity toward the replication of a Penicillium digitatum DNA fragment via PCR (polymerase chain reaction).

JournalTetrahedron
Journal citation63 (44), pp. 10758-10763
ISSN00404020
Year2007
PublisherElsevier
Digital Object Identifier (DOI)doi:10.1016/j.tet.2007.06.123
Web address (URL)https://doi.org/10.1016/j.tet.2007.06.123
Publication dates
Print29 Oct 2007
Publication process dates
Deposited18 Aug 2017
Accepted05 Jun 2007
Copyright information© Elsevier 2007
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