Calix[4]arene Decorated with Four Tn Antigen Glycomimetic Units and P3CS Immunoadjuvant: Synthesis, Characterization, and Anticancer Immunological Evaluation
Article
Geraci, Corrada, Consoli, Grazia M. L., Galante, E., Bousquet, Ennio, Pappalardo, Maria and Spadaro, Angelo 2008. Calix[4]arene Decorated with Four Tn Antigen Glycomimetic Units and P3CS Immunoadjuvant: Synthesis, Characterization, and Anticancer Immunological Evaluation. Bioconjugate Chemistry. 19 (3), pp. 751-758. https://doi.org/10.1021/bc700411w
Authors | Geraci, Corrada, Consoli, Grazia M. L., Galante, E., Bousquet, Ennio, Pappalardo, Maria and Spadaro, Angelo |
---|---|
Abstract | A novel anticancer vaccine candidate built on a nonpeptidic scaffold has been synthesized. Four S-Tn tumor-associated glycomimetic antigens have been clustered onto a calix[4]arene scaffold bearing an immunoadjuvant moiety (P3CS). The immunogenicity of the synthetic construct has been investigated by immunization of mice in vivo. ELISA assay has evidenced that the tetravalent construct stimulates a higher production of anti-Tn antigen IgG antibodies when compared to an analogous monovalent compound. This result is ascribable to an antigen cluster effect and makes the reported vaccine candidate a good mimic of the natural motifs present on the mucine surface. |
Journal | Bioconjugate Chemistry |
Journal citation | 19 (3), pp. 751-758 |
ISSN | 1043-1802 |
Year | 2008 |
Publisher | American Chemical Society (ACS) |
Digital Object Identifier (DOI) | https://doi.org/10.1021/bc700411w |
Web address (URL) | https://doi.org/10.1021/bc700411w |
Publication dates | |
23 Feb 2008 | |
Publication process dates | |
Deposited | 18 Aug 2017 |
Accepted | 01 Feb 2008 |
Copyright information | © 2008 American Chemical Society |
Permalink -
https://repository.uel.ac.uk/item/8654y
171
total views0
total downloads1
views this month0
downloads this month