Positive and negative effects of antipsychotic medication: an international online survey of 832 recipients
Read, J. and Williams, James 2019. Positive and negative effects of antipsychotic medication: an international online survey of 832 recipients. Current Drug Safety. 14 (3), pp. 173-181. https://doi.org/10.2174/1574886314666190301152734
|Authors||Read, J. and Williams, James|
Background: Antipsychotic medication is currently the treatment of choice for psychosis, but few studies directly survey the first hand experience of recipients.
Method: An online direct-to-consumer questionnaire was completed by 832 users of antipsychotics, from 30 countries – predominantly USA, UK and Australia. This is the largest such sample to date.
Results: Over half (56%) thought the drugs reduced the problems they were prescribed for, but 27% thought they made them worse. Slightly less people found the drugs generally ‘Helpful’ (41%) than found them ‘Unhelpful’ (43%). While 35% reported that their ‘quality of life’ was ‘improved’, 54% reported that it was made ‘worse’. The average number of adverse effects reported was 11, with an average of five at the ‘severe’ level. Fourteen effects were reported by 57% or more participants, most commonly: ‘Drowsiness, feeling tired, sedation’ (92%), ‘Loss of motivation’ (86%), ‘Slowed thoughts’ (86%), and ‘Emotional numbing’ (85%). Suicidality was reported to be a side effect by 58%. Older people reported particularly poor outcomes and high levels of adverse effects. Duration of treatment was unrelated to positive outcomes but significantly related to negative outcomes. Most respondents (70%) had tried to stop taking the drugs. The most common reasons people wanted to stop were the side effects (64%) and worries about long-term physical health (52%). Most (70%) did not recall being told anything at all about side effects.
Conclusions Clinical implications are discussed, with a particular focus on the principles of informed consent, and involving patients in decision making about their own lives.
|Journal||Current Drug Safety|
|Journal citation||14 (3), pp. 173-181|
|Publisher||Bentham Science Publishers|
|Accepted author manuscript|
File Access Level
|Digital Object Identifier (DOI)||https://doi.org/10.2174/1574886314666190301152734|
|Web address (URL)||https://doi.org/10.2174/1574886314666190301152734|
|Online||05 Mar 2019|
|Publication process dates|
|Deposited||11 Mar 2019|
|Accepted||01 Mar 2019|
|Accepted||01 Mar 2019|
|Copyright holder||© 2019 Bentham Science Publishers|
|Copyright information||The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1574886314666190301152734.|
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