Dynamics of brain connectivity after stroke

Article

Desowska, A. and Turner, D. 2019. Dynamics of brain connectivity after stroke. Reviews in the Neurosciences. 30 (6), p. 605–623. https://doi.org/10.1515/revneuro-2018-0082

Publication dates
Authors	Desowska, A. and Turner, D.
Abstract	PURPOSE: Recovery from a stroke is a dynamic time-dependent process with the central nervous system reorganizing to accommodate for the impact of the injury. The purpose of this paper is to review recent longitudinal studies of changes in brain connectivity after stroke. METHOD: A systematic review of research papers reporting functional or effective connectivity at two or more time points in stroke patients. RESULTS: Stroke leads to an early reduction of connectivity in the motor network. With recovery time, the connectivity increases and can reach the same levels as in healthy participants. The increase in connectivity is correlated with functional motor gains. A new, more randomized pattern of connectivity may then emerge in the longer term. In some instances, a pattern of increased connectivity even higher than in healthy controls can be observed, related either to a specific time point or to a specific neural structure. Rehabilitation interventions can help improve connectivity between specific regions. CONCLUSIONS: Motor network connectivity undergoes reorganization during recovery from a stroke and can be related to behavioural recovery. Detailed analysis of changes in connectivity pattern may enable a better understanding of adaptation to a stroke and how compensatory mechanisms in the brain may be supported by rehabilitation.
Journal	Reviews in the Neurosciences
Journal citation	30 (6), p. 605–623
ISSN	0334-1763
Year	2019
Publisher	De Gruyter
Accepted author manuscript	7834.pdf License All rights reserved File Access Level Anyone
Digital Object Identifier (DOI)	https://doi.org/10.1515/revneuro-2018-0082
Web address (URL)	https://doi.org/10.1515/revneuro-2018-0082
Online	15 Feb 2019
Publication process dates
Deposited	11 Feb 2019
Accepted	18 Nov 2018
Accepted	18 Nov 2018
Copyright holder	© 2019 Walter de Gruyter GmbH

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