Developmental outcomes of 3,4-methylenedioxymethamphetamine (ecstasy)-exposed infants in the UK

Article

Singer, Lynn T., Moore, Derek G., Min, Meeyoung O., Goodwin, Julia, Turner, J., Fulton, Sarah and Parrott, Andrew C. 2015. Developmental outcomes of 3,4-methylenedioxymethamphetamine (ecstasy)-exposed infants in the UK. Human Psychopharmacology: Clinical and Experimental. 30 (4), pp. 290-294. https://doi.org/10.1002/hup.2459
AuthorsSinger, Lynn T., Moore, Derek G., Min, Meeyoung O., Goodwin, Julia, Turner, J., Fulton, Sarah and Parrott, Andrew C.
Abstract

Objective—This paper aims to review findings from a longitudinal study of prenatal methylenedioxymethamphetamine (MDMA, “ecstasy”) on infant development.
Methods—In a prospective, longitudinal cohort design, we followed 28 MDMA-exposed and 68 non-MDMA-exposed infants from birth to 2 years of age. Women recruited voluntarily into a study of recreational drug use during pregnancy were interviewed to obtain type, frequency, and amount of recreational drug use. Their children were followed for a 2-year period after birth. A large number of drug and environmental covariates were controlled. Infants were seen at 1, 4, 12, 18, and 24 months using standardized normative tests of mental and motor development.
Results—There were no differences between MDMA-exposed and non-MDMA-exposed infants at birth except that MDMA-exposed infants were more likely to be male. Motor delays were evident in MDMA infants at each age and amount of MDMA exposure predicted motor deficits at 12 months in a dose-dependent fashion.
Conclusions—Prenatal MDMA exposure is related to fine and gross motor delays in the first 2 years of life. Follow-up studies are needed to determine long-term effects.

JournalHuman Psychopharmacology: Clinical and Experimental
Journal citation30 (4), pp. 290-294
ISSN08856222
Year2015
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1002/hup.2459
Web address (URL)https://doi.org/10.1002/hup.2459
Publication dates
Online28 Jul 2015
Publication process dates
Deposited01 Aug 2018
Accepted05 Dec 2014
Accepted05 Dec 2014
FunderNational Institute on Drug Abuse
Permalink -

https://repository.uel.ac.uk/item/85545

Log in to edit

  • 157
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Predictors of Suicide Attempts in Male UK Gamblers Seeking Residential Treatment
Sharman, S., Murphy, R., Turner, J. and Roberts, A. 2021. Predictors of Suicide Attempts in Male UK Gamblers Seeking Residential Treatment. Addictive Behaviors. 126 (Art. 107171). https://doi.org/10.1016/j.addbeh.2021.107171
Review: Non‐invasive brain stimulation in behavioral addictions: insights from direct comparisons with substance use disorders
Gomis Vicent, E., Thoma, V., Turner, J., Hill, K. P. and Pascual‐Leone, A. 2019. Review: Non‐invasive brain stimulation in behavioral addictions: insights from direct comparisons with substance use disorders. The American Journal on Addictions. 28 (6), pp. 431-454. https://doi.org/10.1111/ajad.12945
Psychosocial Risk Factors in Disordered Gambling: A Descriptive Systematic Overview of Vulnerable Populations
Sharman, S., Murphy, R., Turner, J. and Roberts, A. 2019. Psychosocial Risk Factors in Disordered Gambling: A Descriptive Systematic Overview of Vulnerable Populations. Addictive Behaviors. 99 (Art. 106071). https://doi.org/10.1016/j.addbeh.2019.106071
Predictors of Dropout in Disordered Gamblers in UK Residential Treatment
Roberts, A., Murphy, R., Turner, J. and Sharman, S. 2019. Predictors of Dropout in Disordered Gamblers in UK Residential Treatment. Journal of Gambling Studies. 36, p. 373–386. https://doi.org/10.1007/s10899-019-09876-7
Psychosocial correlates in treatment seeking gamblers: Differences in early age onset gamblers vs later age onset gamblers
Sharman, S., Murphy, Raegan, Turner, J. and Roberts, Amanda 2019. Psychosocial correlates in treatment seeking gamblers: Differences in early age onset gamblers vs later age onset gamblers. Addictive Behaviors. 97, pp. 20-26. https://doi.org/10.1016/j.addbeh.2019.05.013
Trends and patterns in UK treatment seeking gamblers: 2000–2015
Sharman, S., Murphy, Raegan, Turner, J. and Roberts, Amanda 2018. Trends and patterns in UK treatment seeking gamblers: 2000–2015. Addictive Behaviors. 89, pp. 51-56. https://doi.org/10.1016/j.addbeh.2018.09.009
Psychiatric profiles of mothers who take Ecstasy/MDMA during pregnancy: Reduced depression 1 year after giving birth and quitting Ecstasy
Turner, J., Parrott, Andrew C, Goodwin, Julia, Moore, Derek G, Fulton, Sarah, Min, Meeyoung O and Singer, Lynn T 2014. Psychiatric profiles of mothers who take Ecstasy/MDMA during pregnancy: Reduced depression 1 year after giving birth and quitting Ecstasy. Journal of Psychopharmacology. 28 (1), pp. 55-61. https://doi.org/10.1177/0269881113515061
Aspects of alcohol use disorder affecting social cognition as assessed using the Mini Social and Emotional Assessment (mini-SEA)
Cox, Sharon, Bertoux, Maxime, Turner, J., Moss, Antony, Locker, Kirsty and Riggs, Kevin 2018. Aspects of alcohol use disorder affecting social cognition as assessed using the Mini Social and Emotional Assessment (mini-SEA). Drug and Alcohol Dependence. 187, pp. 165-170. https://doi.org/10.1016/j.drugalcdep.2018.03.004
Novel Psychoactive Substances (NPS): no longer legal, not always highs
Turner, J. and Soar, K. 2017. Novel Psychoactive Substances (NPS): no longer legal, not always highs. University & College Counselling. 2017 (March), pp. 16-21.
Gambling and violence in a nationally representative sample of UK men
Roberts, A., Coid, Jeremy, King, Robert, Murphy, Reagan, Turner, J., Bowden-Jones, Henrietta, Palmer Du Preez, Katie and Landon, Jason 2016. Gambling and violence in a nationally representative sample of UK men. Addiction. 111 (12), pp. 2196-2207. https://doi.org/10.1111/add.13522
Investigating the effects of caffeine on executive functions using traditional Stroop and a new ecologically-valid virtual reality task, the Jansari assessment of Executive Functions (JEF©)
Soar, K., Chapman, E., Sivakuma, N., Jansari, A.S. and Turner, J. 2016. Investigating the effects of caffeine on executive functions using traditional Stroop and a new ecologically-valid virtual reality task, the Jansari assessment of Executive Functions (JEF©). Appetite. 105, pp. 156-163. https://doi.org/10.1016/j.appet.2016.05.021
Motor delays in MDMA (ecstasy) exposed infants persist to 2years
Singer, Lynn T., Moore, D., Min, Meeyoung O., Goodwin, Julia, Turner, J., Fulton, Sarah and Parrott, Andrew C. 2016. Motor delays in MDMA (ecstasy) exposed infants persist to 2years. Neurotoxicology and Teratology. 54, pp. 22-28. https://doi.org/10.1016/j.ntt.2016.01.003
One-Year Outcomes of Prenatal Exposure to MDMA and Other Recreational Drugs
Singer, L.T., Moore, D., Min, M.O., Goodwin, J., Turner, J., Fulton, S. and Parrott, A.C. 2012. One-Year Outcomes of Prenatal Exposure to MDMA and Other Recreational Drugs. Pediatrics. 130 (3), pp. 407-413. https://doi.org/10.1542/peds.2012-0666
MDMA and heightened cortisol: a neurohormonal perspective on the pregnancy outcomes of mothers used ‘Ecstasy’ during pregnancy
Parrott, Andrew C., Moore, D., Turner, J., Goodwin, Julia E., Min, Meeyoung O. and Singer, Lynn T. 2014. MDMA and heightened cortisol: a neurohormonal perspective on the pregnancy outcomes of mothers used ‘Ecstasy’ during pregnancy. Human Psychopharmacology: Clinical and Experimental. 29 (1), pp. 1-7.
‘Vaping’ profiles and preferences: an online survey of electronic cigarette users
Dawkins, L., Turner, J., Roberts, A. and Soar, K. 2013. ‘Vaping’ profiles and preferences: an online survey of electronic cigarette users. Addiction. 108 (6), pp. 1115-1125. https://doi.org/10.1111/add.12150
Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers
Dawkins, L., Turner, J. and Crowe, Eadaoin 2013. Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers. Psychopharmacology. 227 (3), pp. 377-384. https://doi.org/10.1007/s00213-013-2983-2
The electronic-cigarette: effects on desire to smoke, withdrawal symptoms and cognition
Dawkins, L., Turner, J., Hasna, Surrayyah and Soar, K. 2012. The electronic-cigarette: effects on desire to smoke, withdrawal symptoms and cognition. Addictive Behaviors. 37 (8), pp. 970-973.
Attributions for psychobiological changes in ecstasy/MDMA and other polydrug users
Soar, K., Parrott, A.C. and Turner, J. 2009. Attributions for psychobiological changes in ecstasy/MDMA and other polydrug users. Journal of Psychopharmacology. 23 (7), pp. 745-758.
During pregnancy, recreational drug-using women stop taking ecstasy (3,4-methylenedioxy-N-methylamphetamine) and reduce alcohol consumption but continue to smoke tobacco and cannabis
Moore, D., Turner, J., Parrott, A.C., Goodwin, J.E., Fulton, S., Min, M.O., Fox, H.C., Braddick, F.M.B., Toplis, A.S., Axelsson, E.L., Lynch, S., Ribeiro, H., Frostick, C. and Singer, L.T. 2010. During pregnancy, recreational drug-using women stop taking ecstasy (3,4-methylenedioxy-N-methylamphetamine) and reduce alcohol consumption but continue to smoke tobacco and cannabis. Journal of Psychopharmacology. 24 (9), pp. 1403-1410.
In-utero exposure to the popular ‘recreational’ drugs MDMA (Ecstasy) and Methamphetamine (Ice, Crystal): preliminary findings
Moore, D., Turner, J., Goodwin, J.E., Fulton, S.E., Singer, L.T. and Parrott, A.C. 2011. In-utero exposure to the popular ‘recreational’ drugs MDMA (Ecstasy) and Methamphetamine (Ice, Crystal): preliminary findings. in: Preece, P.M. and Riley, E.P. (ed.) Alcohol, drugs and medication in pregnancy: the long-term outcome for the child John Wiley & Sons.