Dr Francesca Mazzacuva


NameDr Francesca Mazzacuva
Job titleSenior Lecturer
Email addressf.mazzacuva@uel.ac.uk
Research instituteHealth, Sport & Bioscience

Research outputs

Evaluating thermogravimetric analysis for the measurement of drug loading in mesoporous silica nanoparticles (MSNs)

Almaghrabi, M., Alqurshi, A., Jadhav, S. A., Mazzacuva, F., Cilibrizzi, A., Raimi-Abraham, B. and Royall, P. G. 2023. Evaluating thermogravimetric analysis for the measurement of drug loading in mesoporous silica nanoparticles (MSNs). Thermochimica Acta. 730 (Art. 179616). https://doi.org/10.1016/j.tca.2023.179616

Optimization of 4-amino-pyridazin-3(2H)-one as a valid core scaffold for FABP4 inhibitors

Floresta, G., Crocetti, L., Rodrigues de Oliveria Silva, R., Patamia, V., Mazzacuva, F., Chen, Y. C. S., Vergelli, C. and Cilibrizzi, A. 2023. Optimization of 4-amino-pyridazin-3(2H)-one as a valid core scaffold for FABP4 inhibitors. Archiv der Pharmazie. 356 (10), p. 2300314. https://doi.org/10.1002/ardp.202300314

PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes

Jian, J., Mazzacuva, F., Crocetti, L., Giovannoni, M. P. and Cilibrizzi, A. 2023. PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes. International Journal of Molecular Sciences. 24 (14), p. 11518. https://doi.org/10.3390/ijms241411518

Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition

Crocetti, L., Floresta, G., Zagni, C., Merugu, D., Mazzacuva, F., Rodrigues de Oliveira Silva, R., Vergelli, C., Giovannoni, M. P. and Cilibrizzi, A. 2022. Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition. Pharmaceuticals. 15 (11), p. 1335. https://doi.org/10.3390/ph15111335

The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay

Mesnage, R., Gerguson, S., Brandsma, I., Moelijker, N., Zhang, G., Mazzacuva, F., Caldwell, A., Halket, J. and Antoniou, M. N. 2022. The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay. Food and Chemical Toxicology. 168 (Art. 113380). https://doi.org/10.1016/j.fct.2022.113380

Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation

Khalil, Y., Carrino, S., Lin, F., Ferlin, A., Lad, H. V., Mazzacuva, F., Falcone, S., Rivers, N., Banks, G., Concas, D., Aguilar, C., Haynes, A. R., Blease, A., Nicol, T., Al-Shawi, R., Heywood, W., Potter, P., Mills, K., Gale, D. P. and Clayton, P. T. 2022. Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation. International Journal of Molecular Sciences. 23 (Art. 987). https://doi.org/10.3390/ijms23020987

OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine

Hesketh, L. M., Sikkel, M. B., Mahoney-Sanchez, L., Mazzacuva, F., Chowdury, R. A., Tzortzis, K. N., Firth, J., MacLeod, K. T., Ogrodzinski, S., Wilder, C. D. E., Pattersone, L. H., Peters, N. S. and Curtis, M. J. 2022. OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine. British Journal of Pharmacology. 179 (9), pp. 2037-2053. https://doi.org/10.1111/bph.15764

Urinary excretion of herbicide co-formulants after oral exposure to roundup MON 52276 in rats

Mesnage, R., Mazzacuva, F., Caldwell, A., Halket, J. and Antoniou, M. N. 2021. Urinary excretion of herbicide co-formulants after oral exposure to roundup MON 52276 in rats. International Journal of Environmental Research and Public Health. 197 (Art. 111103). https://doi.org/10.1016/j.envres.2021.111103

Use of Shotgun Metagenomics and Metabolomics to Evaluate the Impact of Glyphosate or Roundup MON 52276 on the Gut Microbiota and Serum Metabolome of Sprague-Dawley Rats

Mesnage, R., Teixeira, M., Mandrioli, D., Falcioni, L., Zwittink, D., Mazzacuva, F., Caldwell, A., Halket, J., Amiel, C., Panoff, J-M., Belpoggi, F. and Antoniou, M. N. 2021. Use of Shotgun Metagenomics and Metabolomics to Evaluate the Impact of Glyphosate or Roundup MON 52276 on the Gut Microbiota and Serum Metabolome of Sprague-Dawley Rats. Environmental Health Perspectives. 129 (1). https://doi.org/10.1289/EHP6990
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