Urinary excretion of herbicide co-formulants after oral exposure to roundup MON 52276 in rats

Article


Mesnage, R., Mazzacuva, F., Caldwell, A., Halket, J. and Antoniou, M. N. 2021. Urinary excretion of herbicide co-formulants after oral exposure to roundup MON 52276 in rats. International Journal of Environmental Research and Public Health. 197 (Art. 111103). https://doi.org/10.1016/j.envres.2021.111103
AuthorsMesnage, R., Mazzacuva, F., Caldwell, A., Halket, J. and Antoniou, M. N.
Abstract

The toxicity of surfactants, which are an integral component of glyphosate-formulated products is an underexplored and highly debated subject. Since biomonitoring human exposure to glyphosate co-formulants is considered as a public health priority, we developed and validated a high-resolution mass spectrometry method to measure the urinary excretion of surfactants present in Roundup MON 52276, the European Union (EU) representative formulation of glyphosate-based herbicides. Quantification was performed measuring the 5 most abundant compounds in the mixture. We validated the method and showed that it is highly accurate, precise and reproducible with a limit of detection of 0.0004 μg/mL. We used this method to estimate the oral absorption of MON 52276 surfactants in Sprague-Dawley rats exposed to three concentrations of MON 52276 via drinking water for 90 days. MON 52276 surfactants were readily detected in urine of rats administered with this commercial Roundup formulation starting from a low concentration corresponding to the EU glyphosate acceptable daily intake. Our results provide a first step towards the implementation of surfactant co-formulant biomonitoring in human populations.

JournalInternational Journal of Environmental Research and Public Health
Journal citation197 (Art. 111103)
ISSN0013-9351
Year2021
PublisherElsevier
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Anyone
Supplemental file
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.1016/j.envres.2021.111103
Publication dates
Online01 Apr 2021
Publication process dates
Deposited22 Feb 2024
FunderSustainable Food Alliance (USA)
Sheepdrove Trust (UK)
Copyright holder© 2021, The Authors
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