Urinary excretion of herbicide co-formulants after oral exposure to roundup MON 52276 in rats
Article
Mesnage, R., Mazzacuva, F., Caldwell, A., Halket, J. and Antoniou, M. N. 2021. Urinary excretion of herbicide co-formulants after oral exposure to roundup MON 52276 in rats. International Journal of Environmental Research and Public Health. 197 (Art. 111103). https://doi.org/10.1016/j.envres.2021.111103
Authors | Mesnage, R., Mazzacuva, F., Caldwell, A., Halket, J. and Antoniou, M. N. |
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Abstract | The toxicity of surfactants, which are an integral component of glyphosate-formulated products is an underexplored and highly debated subject. Since biomonitoring human exposure to glyphosate co-formulants is considered as a public health priority, we developed and validated a high-resolution mass spectrometry method to measure the urinary excretion of surfactants present in Roundup MON 52276, the European Union (EU) representative formulation of glyphosate-based herbicides. Quantification was performed measuring the 5 most abundant compounds in the mixture. We validated the method and showed that it is highly accurate, precise and reproducible with a limit of detection of 0.0004 μg/mL. We used this method to estimate the oral absorption of MON 52276 surfactants in Sprague-Dawley rats exposed to three concentrations of MON 52276 via drinking water for 90 days. MON 52276 surfactants were readily detected in urine of rats administered with this commercial Roundup formulation starting from a low concentration corresponding to the EU glyphosate acceptable daily intake. Our results provide a first step towards the implementation of surfactant co-formulant biomonitoring in human populations. |
Journal | International Journal of Environmental Research and Public Health |
Journal citation | 197 (Art. 111103) |
ISSN | 0013-9351 |
Year | 2021 |
Publisher | Elsevier |
Publisher's version | License File Access Level Anyone |
Supplemental file | File Access Level Anyone |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.envres.2021.111103 |
Publication dates | |
Online | 01 Apr 2021 |
Publication process dates | |
Deposited | 22 Feb 2024 |
Funder | Sustainable Food Alliance (USA) |
Sheepdrove Trust (UK) | |
Copyright holder | © 2021, The Authors |
https://repository.uel.ac.uk/item/8x561
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1-s2.0-S0013935121003972-main.pdf | ||
License: CC BY 4.0 | ||
File access level: Anyone |
Supplemental file
1-s2.0-S0013935121003972-mmc1.pdf | ||
File access level: Anyone |
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