Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition

Article


Crocetti, L., Floresta, G., Zagni, C., Merugu, D., Mazzacuva, F., Rodrigues de Oliveira Silva, R., Vergelli, C., Giovannoni, M. P. and Cilibrizzi, A. 2022. Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition. Pharmaceuticals. 15 (11), p. 1335. https://doi.org/10.3390/ph15111335
AuthorsCrocetti, L., Floresta, G., Zagni, C., Merugu, D., Mazzacuva, F., Rodrigues de Oliveira Silva, R., Vergelli, C., Giovannoni, M. P. and Cilibrizzi, A.
Abstract

Fatty acid binding protein (FABP4) inhibitors are of synthetic and therapeutic interest and ongoing clinical studies indicate that they may be a promise for the treatment of cancer, as well as other diseases. As part of a broader research effort to develop more effective FABP4 inhibitors, we sought to identify new structures through a two-step computing assisted molecular design based on the established scaffold of a co-crystallized ligand. Novel and potent FABP4 inhibitors have been developed using this approach and herein we report the synthesis, biological evaluation and molecular docking of the 4-amino and 4-ureido pyridazinone-based series.

JournalPharmaceuticals
Journal citation15 (11), p. 1335
ISSN1424-8247
Year2022
PublisherMDPI
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.3390/ph15111335
Publication dates
Online28 Oct 2022
Publication process dates
Accepted21 Oct 2022
Deposited22 Feb 2024
FunderCAPES
Copyright holder© 2022, The Authors
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