Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances
Article
Hassan, Hatem A.F.M., Diebold, Sandra S., Smyth, L., Walters, Adam A., Lombardi, Giovanna and Al-Jamal, Khuloud T. 2019. Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances. Journal of Controlled Release. 297, pp. 79-90. https://doi.org/10.1016/j.jconrel.2019.01.017
Authors | Hassan, Hatem A.F.M., Diebold, Sandra S., Smyth, L., Walters, Adam A., Lombardi, Giovanna and Al-Jamal, Khuloud T. |
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Abstract | Tumour-specific, immuno-based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano-vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy-dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano-vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing. |
Journal | Journal of Controlled Release |
Journal citation | 297, pp. 79-90 |
ISSN | 0168-3659 |
Year | 2019 |
Publisher | Elsevier for Controlled Release Society and Japan Society of Drug Delivery System |
Accepted author manuscript | License |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jconrel.2019.01.017 |
Web address (URL) | https://doi.org/10.1016/j.jconrel.2019.01.017 |
Publication dates | |
Online | 16 Jan 2019 |
Publication process dates | |
Deposited | 22 Jan 2019 |
Accepted | 14 Jan 2019 |
Accepted | 14 Jan 2019 |
Funder | Biotechnology and Biological Sciences Research Council |
Worldwide Cancer Research | |
Biotechnology and Biological Sciences Research Council | |
Worldwide Cancer Research | |
Copyright information | © 2019 Elsevier |
https://repository.uel.ac.uk/item/844zy
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