Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances

Article


Hassan, Hatem A.F.M., Diebold, Sandra S., Smyth, L., Walters, Adam A., Lombardi, Giovanna and Al-Jamal, Khuloud T. 2019. Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances. Journal of Controlled Release. 297, pp. 79-90.
AuthorsHassan, Hatem A.F.M., Diebold, Sandra S., Smyth, L., Walters, Adam A., Lombardi, Giovanna and Al-Jamal, Khuloud T.
Abstract

Tumour-specific, immuno-based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano-vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy-dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano-vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing.

JournalJournal of Controlled Release
Journal citation297, pp. 79-90
ISSN0168-3659
Year2019
PublisherElsevier for Controlled Release Society and Japan Society of Drug Delivery System
Accepted author manuscript
License
Digital Object Identifier (DOI)doi:10.1016/j.jconrel.2019.01.017
Web address (URL)https://doi.org/10.1016/j.jconrel.2019.01.017
Publication dates
Online16 Jan 2019
Publication process dates
Deposited22 Jan 2019
Accepted14 Jan 2019
Accepted14 Jan 2019
FunderBiotechnology and Biological Sciences Research Council
Worldwide Cancer Research
Biotechnology and Biological Sciences Research Council
Worldwide Cancer Research
Copyright information© 2019 Elsevier
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Accepted author manuscript

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