Treg therapy in transplantation a general overview

Article


Romano, Marco, Tung, Sim Lai, Smyth, L. and Lombardi, Giovanna 2016. Treg therapy in transplantation a general overview. Transplant International. 30 (8), pp. 745-753.
AuthorsRomano, Marco, Tung, Sim Lai, Smyth, L. and Lombardi, Giovanna
Abstract

Solid organ transplantation remains the treatment of choice for end
-stage organ failure. Whilst the
short term outcomes post
-transplant have improved in the last decades, chronic rejection and
immunosuppressant side effects remain an ongoing concern. Hematopoietic stem cell
transplantation is a well
-established procedure for the treatment of patients with haematological
disorders. However, donor T
-cells are continually primed and activated to react against the host
causing graft
-versus
-host
-disease (GvHD) that leads to tissue damages and death. Regulatory T
-cells
(Tregs) play an essential role in maintaining tolerance to self
-antigens, preventing excessive immune
responses and abrogating autoimmunity. Due to their suppressive properties, Tregs have been
extensively studied for their use as a cellular therapy aiming to treat GvHD and limit immune
responses responsible for graft rejection. Several clinical trials have been conducted or are currently
Accepted Article
This article is protected by copyright. All rights reserved.
ongoing to investigate safety and feasibility of Treg
-based therapy. This review summarises the
general understanding of Treg biology and presents the methods used to isolate and expand Tregs.
Furthermore, we describe data from the first clinical trials using Tregs, explaining the limitations and
future application of these cells.

KeywordsTransplantation; Regulatory T -cells; Clinical Trials; GMP
JournalTransplant International
Journal citation30 (8), pp. 745-753
ISSN0934-0874
1432-2277
Year2016
PublisherWiley
Accepted author manuscript
License
Digital Object Identifier (DOI)doi:10.1111/tri.12909
Publication dates
Print24 Dec 2016
Publication process dates
Deposited06 Jan 2017
Accepted19 Dec 2016
Accepted19 Dec 2016
Copyright informationThis is the peer reviewed version of the following article: Romano, M., Tung, S. L., Smyth, L. A. and Lombardi, G. (2016), Treg therapy in transplantation a general overview in Transplant International, which has been published in final form at http://dx.doi.org/10.1111/tri.12909. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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