What Is Direct Allorecognition?

Article


Boardman, Dominic A., Jacob, Jacinta, Smyth, L., Lombardi, Giovanna and Lechler, Robert I. 2016. What Is Direct Allorecognition? Current Transplantation Reports. 3 (4), pp. 275-283.
AuthorsBoardman, Dominic A., Jacob, Jacinta, Smyth, L., Lombardi, Giovanna and Lechler, Robert I.
Abstract

Direct allorecognition is the process by which
donor-derived major histocompatibility complex (MHC)-peptide
complexes, typically presented by donor-derived ‘passenger’
dendritic cells, are recognised directly by recipient T cells.
In this review, we discuss the two principle theories which
have been proposed to explain why individuals possess a
high-precursor frequency of T cells with direct allospecificity
and how self-restricted T cells recognise allogeneic MHCpeptide
complexes. These theories, both of which are supported
by functional and structural data, suggest that T cells
recognising allogeneic MHC-peptide complexes focus either
on the allopeptides bound to the allo-MHC molecules or the
allo-MHC molecules themselves. We discuss how direct
alloimmune responses may be sustained long term, the consequences
of this for graft outcome and highlight novel strategies
which are currently being investigated as a potential
means of reducing rejection mediated through this pathway.

KeywordsTransplantation; Allospecificity; Allorecognition; Multiple binary complexes; High determinant density
JournalCurrent Transplantation Reports
Journal citation3 (4), pp. 275-283
ISSN2196-3029
Year2016
PublisherSpringer Verlag
Publisher's version
File Access Level
Repository staff only
Publisher's version
License
Digital Object Identifier (DOI)doi:10.1007/s40472-016-0115-8
Web address (URL)https://doi.org/10.1007/s40472-016-0115-8
Publication dates
Print07 Oct 2016
Publication process dates
Deposited26 Oct 2016
FunderDepartment of Health
Medical Research Council (MRC) Centre for Transplantation
British Heart Foundation (BHF)
Medical Research Council
British Heart Foundation
Department of Health
Copyright information© The Authors 2016
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