The Effect of Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation Intensity

Article

Premoli, Isabella, Costantini, Alyssa, Rivolta, D., Biondi, Andrea and Richardson, Mark P. 2017. The Effect of Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation Intensity. Frontiers in Neuroscience. 11, p. Art. 585. https://doi.org/10.3389/fnins.2017.00585
AuthorsPremoli, Isabella, Costantini, Alyssa, Rivolta, D., Biondi, Andrea and Richardson, Mark P.
Abstract

The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has uncovered underlying mechanisms of two anti-epileptic medications: levetiracetam and lamotrigine. Despite their different mechanism of action, both drugs modulated TMS-evoked EEG potentials (TEPs) in a similar way. Since both medications increase resting motor threshold (RMT), the current aim was to examine the similarities and differences in post-drug TEPs, depending on whether stimulation intensity was adjusted to take account of post-drug RMT increase. The experiment followed a placebo controlled, double blind, crossover design, involving a single dose of either lamotrigine or levetiracetam. When a drug-induced increase of RMT occurred, post-drug measurements involved two blocks of stimulations, using unadjusted and adjusted stimulation intensity. A cluster based permutation analysis of differences in TEP amplitude between adjusted and unadjusted stimulation intensity showed that lamotrigine induced a stronger modulation of the N45 TEP component compared to levetiracetam. Results highlight the impact of adjusting stimulation intensity.

JournalFrontiers in Neuroscience
Journal citation11, p. Art. 585
ISSN1662-453X
Year2017
PublisherFrontiers Media
Publisher's version
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Digital Object Identifier (DOI)https://doi.org/10.3389/fnins.2017.00585
Web address (URL)https://doi.org/10.3389/fnins.2017.00585
Publication dates
Print20 Oct 2017
Publication process dates
Deposited11 Jan 2019
Accepted05 Oct 2017
Accepted05 Oct 2017
FunderNational Institute for Health Research
Medical Research Council
Engineering and Physical Sciences Research Council
National Institute for Health Research
Medical Research Council
Engineering and Physical Sciences Research Council
Copyright information© 2017 The authors
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