TMS-EEG Signatures of GABAergic Neurotransmission in the Human Cortex

Article


Premoli, I., Castellanos, N., Rivolta, D., Belardinelli, P., Bajo, R., Zipser, C., Espenhahn, S., Heidegger, T., Muller-Dahlhaus, F. and Ziemann, U. 2014. TMS-EEG Signatures of GABAergic Neurotransmission in the Human Cortex. Journal of Neuroscience. 34 (16), pp. 5603-5612.
AuthorsPremoli, I., Castellanos, N., Rivolta, D., Belardinelli, P., Bajo, R., Zipser, C., Espenhahn, S., Heidegger, T., Muller-Dahlhaus, F. and Ziemann, U.
Abstract

Combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) constitutes a powerful tool to directly assess
human cortical excitability and connectivity. TMS of the primary motor cortex elicits a sequence of TMS-evoked EEG potentials (TEPs).
It is thought that inhibitory neurotransmission through GABA-A receptors (GABAAR) modulates early TEPs (�50 ms after TMS),
whereas GABA-B receptors (GABABR) play a role for later TEPs (at�100 ms after TMS). However, the physiological underpinnings of
TEPs have not been clearly elucidated yet. Here, we studied the role of GABAA/B-ergic neurotransmission for TEPs in healthy subjects
using a pharmaco-TMS-EEG approach. In Experiment 1, we tested the effects of a single oral dose of alprazolam (a classical benzodiazepine
acting as allosteric-positive modulator at �1, �2, �3, and �5 subunit-containing GABAARs) and zolpidem (a positive modulator
mainly at the�1 GABAAR) in a double-blind, placebo-controlled, crossover study. In Experiment 2, we tested the influence of baclofen (a
GABABRagonist) and diazepam (a classical benzodiazepine) versus placebo on TEPs. Alprazolam and diazepam increased the amplitude
of the negative potential at 45 ms after stimulation (N45) and decreased the negative component at 100 ms (N100), whereas zolpidem
increased the N45 only. In contrast, baclofen specifically increased the N100 amplitude. These results provide strong evidence that the
N45 represents activity of �1-subunit-containing GABAARs, whereas the N100 represents activity of GABABRs. Findings open a novel
window of opportunity to study alteration of GABAA-/GABAB-related inhibition in disorders, such as epilepsy or schizophrenia.

JournalJournal of Neuroscience
Journal citation34 (16), pp. 5603-5612
ISSN1529-2401
0270-6474
Year2014
PublisherSociety for Neuroscience
Publisher's version
License
CC BY
Web address (URL)http://dx.doi.org/10.1523/JNEUROSCI.5089-13.2014
Publication dates
Print16 Apr 2014
Publication process dates
Deposited13 Jan 2016
Accepted14 Mar 2014
Copyright information© 2014 The authors
Permalink -

https://repository.uel.ac.uk/item/85q42

  • 10
    total views
  • 56
    total downloads
  • 3
    views this month
  • 4
    downloads this month

Related outputs

The Effect of Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation Intensity
Premoli, Isabella, Costantini, Alyssa, Rivolta, D., Biondi, Andrea and Richardson, Mark P. 2017. The Effect of Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation Intensity. Frontiers in Neuroscience. 11, p. Art. 585.
Transcranial alternating current stimulation (tACS) at 40 Hz enhances face and object perception
Gonzalez Perez, M., Wakui, E., Thoma, V., Nitsche, M. A. and Rivolta, D. 2019. Transcranial alternating current stimulation (tACS) at 40 Hz enhances face and object perception. Neuropsychologia.
Anodal tDCS and High-Frequency tRNS Targeting the Occipitotemporal Cortex Do Not Always Enhance Face Perception
Willis, M. L., Costantino, A., Nitsche, M. A., Palermo, R. and Rivolta, D. 2019. Anodal tDCS and High-Frequency tRNS Targeting the Occipitotemporal Cortex Do Not Always Enhance Face Perception. Frontiers in Neuroscience. 13 (Art. 78).
Preliminary Evidence of “Other-Race Effect”-Like Behavior Induced by Cathodal-tDCS over the Right Occipital Cortex, in the Absence of Overall Effects on Face/Object Processing
Costantino, Andrea I., Titoni, Matilde, Bossi, Francesco, Premoli, Isabella, Nitsche, Michael A. and Rivolta, D. 2017. Preliminary Evidence of “Other-Race Effect”-Like Behavior Induced by Cathodal-tDCS over the Right Occipital Cortex, in the Absence of Overall Effects on Face/Object Processing. Frontiers in Neuroscience. 11, p. Art 661.
Neurophysiological Correlates of Featural and Spacing Processing for Face and Non-face Stimuli
Negrini, Marcello, Brkić, Diandra, Pizzamiglio, Sara, Premoli, Isabella and Rivolta, D. 2017. Neurophysiological Correlates of Featural and Spacing Processing for Face and Non-face Stimuli. Frontiers in Psychology. 8 (333).
The perception of (naked only) bodies and faceless heads relies on holistic processing: Evidence from the inversion effect
Bonemei, Rob, Costantino, Andrea I., Battistel, Ilenia and Rivolta, D. 2017. The perception of (naked only) bodies and faceless heads relies on holistic processing: Evidence from the inversion effect. British Journal of Psychology. 109 (2), pp. 232-243.
MEG-measured visually induced gamma-band oscillations in chronic schizophrenia: Evidence for impaired generation of rhythmic activity in ventral stream regions
Grent-‘t-Jong, Tineke, Rivolta, D., Sauer, Andreas, Grube, Michael, Singer, Wolf, Wibral, Michael and Uhlhaas, Peter J. 2016. MEG-measured visually induced gamma-band oscillations in chronic schizophrenia: Evidence for impaired generation of rhythmic activity in ventral stream regions. Schizophrenia Research. 176 (2-3), pp. 177-185.
Face matching impairment in developmental prosopagnosia
White, David, Rivolta, D., Burton, A. Mike, Al-Janabi, Shahd and Palermo, Romina 2016. Face matching impairment in developmental prosopagnosia. The Quarterly Journal of Experimental Psychology. 70 (2), pp. 287-297.
More than just a problem with faces: Altered body perception in a group of congenital prosopagnosics
Rivolta, D., Lawson, Rebecca P. and Palermo, Romina 2016. More than just a problem with faces: Altered body perception in a group of congenital prosopagnosics. The Quarterly Journal of Experimental Psychology. 70 (2), pp. 276-286.
Do people have insight into their face recognition abilities?
Palermo, Romina, Rossion, Bruno, Rhodes, Gillian, Laguesse, Renaud, Tez, Tolga, Hall, Bronwyn, Albonico, Andrea, Malaspina, Manuela, Daini, Roberta, Irons, Jessica, Al-Janabi, Shahd, Taylor, Libby C., Rivolta, D. and McKone, Elinor 2016. Do people have insight into their face recognition abilities? Quarterly Journal of Experimental Psychology. 70 (2), pp. 218-233.
Editorial: Facing the Other: Novel Theories and Methods in Face Perception Research
Rivolta, D., Puce, Aina and Williams, Mark A. 2016. Editorial: Facing the Other: Novel Theories and Methods in Face Perception Research. Frontiers in Human Neuroscience. 10.
Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects
Barbieri, Marica, Negrini, Marcello, Nitsche, Michael A. and Rivolta, D. 2015. Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects. Neuropsychologia. 81 (29 Jan), pp. 238-244.
Lamotrigine and levetiracetam exert a similar modulation of TMS-evoked EEG potentials
Premoli, Isabella, Biondi, Andrea, Carlesso, Sara, Rivolta, D. and Richardson, Mark P. 2016. Lamotrigine and levetiracetam exert a similar modulation of TMS-evoked EEG potentials. Epilepsia. 58 (1), pp. 42-50.
Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing
Rivolta, D., Castellanos, N. P., Stawowsky, C., Helbling, S., Wibral, M., Grutzner, C., Koethe, D., Birkner, K., Kranaster, L., Enning, F., Singer, W., Leweke, F. M. and Uhlhaas, P. J. 2014. Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing. Journal of Neuroscience. 34 (17), pp. 5909-5917.
Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings
Rivolta, D., Heidegger, T., Scheller, B., Sauer, A., Schaum, M., Birkner, K., Singer, W., Wibral, M. and Uhlhaas, P. J. 2015. Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings. Schizophrenia Bulletin.
Multi-voxel pattern analysis (MVPA) reveals abnormal fMRI activity in both the 'core' and 'extended' face network in congenital prosopagnosia
Rivolta, D., Woolgar, Alexandra, Palermo, Romina, Butko, Marina, Schmalzl, Laura and Williams, Mark A. 2014. Multi-voxel pattern analysis (MVPA) reveals abnormal fMRI activity in both the 'core' and 'extended' face network in congenital prosopagnosia. Frontiers in Human Neuroscience. 8 (925).
Using hypnosis to disrupt face processing: mirrored-self misidentification delusion and different visual media
Connors, Michael H., Barnier, Amanda J., Coltheart, Max, Langdon, Robyn, Cox, Rochelle E., Rivolta, D. and Halligan, Peter W. 2014. Using hypnosis to disrupt face processing: mirrored-self misidentification delusion and different visual media. Frontiers in Human Neuroscience. 8 (361).
Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS–EEG
Premoli, Isabella, Rivolta, D., Espenhahn, Svenja, Castellanos, Nazareth, Belardinelli, Paolo, Ziemann, Ulf and Müller-Dahlhaus, Florian 2014. Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS–EEG. NeuroImage. 103 (Dec), pp. 152-162.