Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Article


Gibson, Greg, Pillas, Demetris, Hoggart, Clive J., Evans, David M., O'Reilly, Paul F., Sipilä, Kirsi, Lähdesmäki, Raija, Millwood, Iona Y., Kaakinen, Marika, Netuveli, G., Blane, David, Charoen, Pimphen, Sovio, Ulla, Pouta, Anneli, Freimer, Nelson, Hartikainen, Anna-Liisa, Laitinen, Jaana, Vaara, Sarianna, Glaser, Beate, Crawford, Peter, Timpson, Nicholas J., Ring, Susan M., Deng, Guohong, Zhang, Weihua, McCarthy, Mark I., Deloukas, Panos, Peltonen, Leena, Elliott, Paul, Coin, Lachlan J. M., Smith, George Davey and Jarvelin, Marjo-Riitta 2010. Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy. PLoS Genetics. 6 (2), p. e1000856.
AuthorsGibson, Greg, Pillas, Demetris, Hoggart, Clive J., Evans, David M., O'Reilly, Paul F., Sipilä, Kirsi, Lähdesmäki, Raija, Millwood, Iona Y., Kaakinen, Marika, Netuveli, G., Blane, David, Charoen, Pimphen, Sovio, Ulla, Pouta, Anneli, Freimer, Nelson, Hartikainen, Anna-Liisa, Laitinen, Jaana, Vaara, Sarianna, Glaser, Beate, Crawford, Peter, Timpson, Nicholas J., Ring, Susan M., Deng, Guohong, Zhang, Weihua, McCarthy, Mark I., Deloukas, Panos, Peltonen, Leena, Elliott, Paul, Coin, Lachlan J. M., Smith, George Davey and Jarvelin, Marjo-Riitta
Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10−8, and 5 with suggestive association (P<5×10−6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.

JournalPLoS Genetics
Journal citation6 (2), p. e1000856
ISSN1553-7404
Year2010
Publisher's version
License
CC BY
Web address (URL)http://dx.doi.org/10.1371/journal.pgen.1000856
Publication dates
Print26 Feb 2010
Publication process dates
Deposited26 Nov 2013
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