Depression Earlier on in Life Predicts Frailty at 50 Years: Evidence from the 1958 British Birth Cohort Study

Article


Watts, P., Menon, M. and Netuveli, G. 2023. Depression Earlier on in Life Predicts Frailty at 50 Years: Evidence from the 1958 British Birth Cohort Study. Journal of Clinical Medicine. 12 (17), p. 5568. https://doi.org/10.3390/jcm12175568
AuthorsWatts, P., Menon, M. and Netuveli, G.
Abstract

Frailty and depression in older ages have a bidirectional relationship, sharing some symptoms and characteristics. Most evidence for this has come from cross-sectional studies, or longitudinal studies with limited follow-up periods. We used data from the National Child Development Study (1958 Birth Cohort) to investigate the relationship between depression and early-onset frailty using a life course perspective. The primary outcome was frailty based on a 30-item inventory of physical health conditions, activities of daily living and cognitive function at 50 years. The main exposure was depression (based on a nine-item Malaise score ≥ 4) measured at 23, 33 and 42 years. We investigated this relationship using multiple logistic regression models adjusted for socio-demographic factors, early life circumstances and health behaviours. In fully adjusted models, when modelled separately, depression at each timepoint was associated with around twice the odds of frailty. An accumulated depression score showed increases in the odds of frailty with each unit increase (once: OR 1.92, 95%CI 1.65, 2.23; twice OR 2.33, 95%CI 1.85, 2.94; thrice: OR 2.95, 95%CI 2.11, 4.11). The public health significance of this finding is that it shows the potential to reduce the physical burden of disease later in life by paying attention to mental health at younger ages.

JournalJournal of Clinical Medicine
Journal citation12 (17), p. 5568
ISSN 2077-0383
Year2023
PublisherMDPI
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Digital Object Identifier (DOI)https://doi.org/10.3390/jcm12175568
Publication dates
Online26 Aug 2023
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Accepted18 Aug 2023
Deposited29 Aug 2023
Copyright holder© 2023, The Author(s)
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