Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE)

Article


Edmonds, C., Helps, A., Hart, D., Zatorska, A. M., Gupta, N., Cianfaglione, R. and Vollmer, B. 2020. Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE). European Journal of Paediatric Neurology. 27, pp. 78-85. https://doi.org/10.1016/j.ejpn.2020.04.003
AuthorsEdmonds, C., Helps, A., Hart, D., Zatorska, A. M., Gupta, N., Cianfaglione, R. and Vollmer, B.
Abstract

Background: Neurodevelopmental follow-up in Neonatal Hypoxic Ischaemic Encephalopathy (HIE) typically focusses on major neuromotor (cerebral palsy, CP) and severe cognitive impairment. Outcomes in those without major neuromotor impairment are less well explored.

Objectives: To examine behavioural, cognitive and neurological outcomes after neonatal HIE, in a clinical cohort of children without CP, at age 2 years.

Methods: Clinical routine outcome data from children admitted to a tertiary centre with neonatal HIE for hypothermia treatment between 05/08/09 - 30/05/2016. Children were assessed for neuromotor status – particularly minor neurological signs (MNS), with Bayley Scales of Infant and Toddler Development III (Bayley III) or Ages and Stages Questionnaire-3 (ASQ), Child Behavior Checklist 1.5-5 (CBCL), Quantitative Checklist for Autism in Toddlers (Q-CHAT).

Results: Of 107 children, 75.5% had normal neurology, 12.1% CP, 12.1% MNS. Children with CP were excluded from analyses. For those without CP, Bayley-III scores were in the average range for the majority; mild cognitive delay observed in 5%, 4.2% language, 1.3% motor development; severe delay in 1.3% for cognitive, 4.2% for language. More than in the normative population scored in clinical ranges for CBCL externalising, sleep, and other problems. No significant difference was seen for Q-CHAT. Children with MNS were significantly more likely to have impaired Bayley-III scores, parent-reported internalising, sleep, and other problems.

Conclusions: In this clinical cohort, the majority of children had favourable outcome at 2 years. However, children with MNS were at risk for cognitive and behavioural difficulties and will benefit from enhanced clinical follow-up and support.

JournalEuropean Journal of Paediatric Neurology
Journal citation27, pp. 78-85
ISSN1090-3798
Year2020
PublisherElsevier for European Paediatric Neurology Society
Accepted author manuscript
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ejpn.2020.04.003
Web address (URL)https://doi.org/10.1016/j.ejpn.2020.04.003
Publication dates
Online11 Apr 2020
Publication process dates
Accepted07 Apr 2020
Deposited16 Apr 2020
Copyright holder© 2020 Elsevier
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