Dehydration in older people: a systematic review of the effects of dehydration on health outcomes, healthcare costs and cognitive performance

Article


Edmonds, C., Foglia, E., Booth, P., Fu, C. and Gardner, M. 2021. Dehydration in older people: a systematic review of the effects of dehydration on health outcomes, healthcare costs and cognitive performance. Archives of Gerontology and Geriatrics. 95 (Art. 104380). https://doi.org/10.1016/j.archger.2021.104380
AuthorsEdmonds, C., Foglia, E., Booth, P., Fu, C. and Gardner, M.
Abstract

Objective: To systematically examine the effect of dehydration on health outcomes, identify associated financial costs and consider impacts on cognitive performance in older adults.
Design: A systematic review of English-language articles via OVID using MEDLINE, PsychINFO, EMBASE, and others, to March 2018. Included studies examined the relationship between hydration status and health, care costs or cognitive outcome.
Setting: Cross sectional and cohort data from studies reporting on dehydration in older adults.
Participants: Adults aged 60 years and older.
Measurements: Independent quality ratings were assessed for all extracted articles.
Results: Of 1684 articles screened, 18 papers (N = 33,707) met inclusion criteria. Participants were recruited from hospital settings, medical long-term care centres and the community dwelling population. Data were synthesised using a narrative summary. Mortality rates were higher in dehydrated patients. Furthermore, health outcomes, including frailty, bradyarrhythmia, transient ischemic attacks, oral health and surgery recovery are linked to and worsened by dehydration. Length of hospital stay, either as a principal or secondary diagnosis, is greater in those with dehydration, compared to those who are euhydrated. Finally, neurocognitive functioning may be impacted by dehydration. There are issues with study design, inconsistency in hydration status measurement and different measures used for outcome assessment.
Conclusion: Dehydration in older people is associated with increased mortality, poorer course of illness and increased costs for health services. In addition, there is some, but sparse evidence that dehydration in older people is linked to poorer cognitive performance. Intervention studies should test strategies for reducing dehydration in older adults.

JournalArchives of Gerontology and Geriatrics
Journal citation95 (Art. 104380)
ISSN0167-4943
Year2021
PublisherElsevier
Accepted author manuscript
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.1016/j.archger.2021.104380
Publication dates
Online17 Feb 2021
Publication process dates
Accepted13 Feb 2021
Deposited16 Feb 2021
Copyright holder© 2021 Elsevier
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Wise, T., Radua, J., Via, E., Cardoner, N., Abe, O., Adams, T. M., Amico, F., Cheng, Y., Cole, J. H., de Azevedo Marques Périco, C., Dickstein, D. P., Farrow, T. F. D., Frodl, T., Wagner, G., Gotlib, I. H., Gruber, O., Ham, B. J., Job, D. E., Kempton, M. J., Kim, M. J., Koolschijn, P. C. M. P., Malhi, G. S., Mataix-Cols, D., McIntosh, A. M., Nugent, A. C., O'Brien, J. T.., Pezzoli, S, Phillips, M. L., Sachdev, P. S., Salvadore, G., Selvaraj, S., Stanfield, A. C., Thomas, A. J., van Tol, M. J., van der Wee, N. J. A., Veltman, D. J., Young, A. H., Fu, C., Cleare, A. J. and Arnone, D. 2016. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis. Molecular Psychiatry. https://doi.org/10.1038/mp.2016.72
'Spontaneous' visual perspective-taking mediated by attention orienting that is voluntary and not reflexive
Gardner, Mark R., Hull, Zainabb, Taylor, Donna and Edmonds, C. 2018. 'Spontaneous' visual perspective-taking mediated by attention orienting that is voluntary and not reflexive. Quarterly Journal of Experimental Psychology. 71 (4), pp. 1020-1029. https://doi.org/10.1080/17470218.2017.1307868
Dose-Response Effects of Water Supplementation on Cognitive Performance and Mood in Children and Adults
Edmonds, C., Crosbie, Laura, Fatima, Fareeha, Hussain, Maryam, Jacob, Nicole and Gardner, Mark 2016. Dose-Response Effects of Water Supplementation on Cognitive Performance and Mood in Children and Adults. Appetite. 108, pp. 464-470. https://doi.org/10.1016/j.appet.2016.11.011
The effect of carbohydrate mouth rinsing on fencing performance and cognitive function following fatigue-inducing fencing
Rowlatt, G., Bottoms, Lindsay, Edmonds, C. and Buscombe, R. 2016. The effect of carbohydrate mouth rinsing on fencing performance and cognitive function following fatigue-inducing fencing. European Journal Of Sport Science. 17 (4), pp. 433-440. https://doi.org/10.1080/17461391.2016.1251497
Diagnostic potential of structural neuroimaging for depression from a multi-ethnic community sample
Sankar, Anjali, Zhang, Tianhao, Gaonkar, Bilwaj, Doshi, Jimit, Erus, Guray, Costafreda, Sergi G., Marangell, Lauren, Davatzikos, Christos and Fu, C. 2016. Diagnostic potential of structural neuroimaging for depression from a multi-ethnic community sample. BJPsych Open. 2 (4), pp. 247-254. https://doi.org/10.1192/bjpo.bp.115.002493
The Effect of Water Consumption on Schoolchildren's Fine Motor Skills, Cognitive Function and Mood
Booth, P. 2015. The Effect of Water Consumption on Schoolchildren's Fine Motor Skills, Cognitive Function and Mood. PhD Thesis University of East London Psychology https://doi.org/10.15123/PUB.5017
Observed bodies generate object-based spatial codes
Taylor, Alison, Flynn, Maria, Edmonds, C. and Gardner, Mark R. 2016. Observed bodies generate object-based spatial codes. Acta Psychologica. 169 (Sep.), pp. 71-78. https://doi.org/10.1016/j.actpsy.2016.05.009
The effect of carbohydrate mouth rinsing on fencing performance and cognitive function following a fatigue inducing simulated bout of fencing in national level foil fencers
Bottoms, L., Rowlatt, Georgina, Edmonds, C. and Buscombe, R. 2016. The effect of carbohydrate mouth rinsing on fencing performance and cognitive function following a fatigue inducing simulated bout of fencing in national level foil fencers. Biomedical Basis of Elite Performance 2016. Nottingham, UK 06 - 08 Mar 2016
The effect of carbohydrate mouth rinse on a 30-minute arm cranking performance
Andersson, H., Sinclair, J., Knight, A., Buscombe, R., Edmonds, C. and Bottoms, L. 2016. The effect of carbohydrate mouth rinse on a 30-minute arm cranking performance. Comparative Exercise Physiology. 12 (1), pp. 41-47. https://doi.org/10.3920/CEP150032
Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes
Moulton, Calum D., Costafreda, Sergi G., Horton, Paul, Ismail, Khalida and Fu, C. 2015. Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes. Brain Imaging and Behavior. 9 (4), pp. 651-662.
A systematic review of the neurophysiology of mindfulness on EEG oscillations
Lomas, T., Ivtzan, I. and Fu, C. 2015. A systematic review of the neurophysiology of mindfulness on EEG oscillations. Neuroscience & Biobehavioral Reviews. 57, pp. 401-410.
Multimodal functional and structural neuroimaging investigation of major depressive disorder following treatment with duloxetine
Fu, C., Costafreda, Sergi G, Sankar, Anjali, Adams, Tracey M, Rasenick, Mark M, Liu, Peng, Donati, Robert, Maglanoc, Luigi A, Horton, Paul and Marangell, Lauren B 2015. Multimodal functional and structural neuroimaging investigation of major depressive disorder following treatment with duloxetine. BMC Psychiatry. 15 (1).
Neural effects of cognitive–behavioural therapy on dysfunctional attitudes in depression
Sankar, A., Scott, J., Paszkiewicz, A., Giampietro, V. P., Steiner, H. and Fu, C. 2014. Neural effects of cognitive–behavioural therapy on dysfunctional attitudes in depression. Psychological Medicine. 45 (7), pp. 1425-1433.
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder
Legge, R. M., Sendi, S., Cole, J. H., Cohen-Woods, S., Costafreda, S. G., Simmons, A., Farmer, A. E., Aitchison, K. J., McGuffin, P. and Fu, C. 2015. Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. The British Journal of Psychiatry. 206 (5), pp. 379-384.
Prognostic and Diagnostic Potential of the Structural Neuroanatomy of Depression
Domschke, Katharina, Costafreda, Sergi G., Chu, Carlton, Ashburner, John and Fu, C. 2009. Prognostic and Diagnostic Potential of the Structural Neuroanatomy of Depression. PLOS ONE. 4 (7), p. e6353.
Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
Costafreda, Sergi G, Fu, C., Picchioni, Marco, Toulopoulou, Timothea, McDonald, Colm, Kravariti, Eugenia, Walshe, Muriel, Prata, Diana, Murray, Robin M and McGuire, Philip K 2011. Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder. BMC Psychiatry. 11 (1), p. 18.
Neuroimaging-Based Biomarkers in Psychiatry: Clinical Opportunities of a Paradigm Shift
Fu, C. and Costafreda, Sergi G. 2013. Neuroimaging-Based Biomarkers in Psychiatry: Clinical Opportunities of a Paradigm Shift. Canadian Journal of Psychiatry. 58 (9), pp. 499-508.
Subjective thirst moderates changes in speed of responding associated with water consumption
Edmonds, C., Crombie, Rosanna and Gardner, Mark R. 2013. Subjective thirst moderates changes in speed of responding associated with water consumption. Frontiers in Human Neuroscience. 7, p. Art363.
Strategy modulates spatial perspective-taking: evidence for dissociable disembodied and embodied routes
Gardner, Mark R, Brazier, Mark, Edmonds, C. and Gronholm, Petra C. 2013. Strategy modulates spatial perspective-taking: evidence for dissociable disembodied and embodied routes. Frontiers in Human Neuroscience. 7, p. Art457.
Water consumption, not expectancies about water consumption, affects cognitive performance in adults
Edmonds, C., Crombie, Rosanna, Baillieux, Haiko, Gardner, Mark R and Dawkins, L. 2013. Water consumption, not expectancies about water consumption, affects cognitive performance in adults. Appetite. 60, pp. 148-153.
Expectation of having consumed caffeine can improve performance and mood
Dawkins, L., Shahzad, Fatima-Zahra, Ahmed, Suada S. and Edmonds, C. 2011. Expectation of having consumed caffeine can improve performance and mood. Appetite. 57 (3), pp. 597-600.
The effect of intra-uterine growth on Verbal IQ scores in childhood: a monozygotic twin study
Edmonds, C., Isaacs, Elizabeth B., Cole, Tim J., Haslinger Rogers, Mary, Lanigan, Julie, Singhal, Atul, Birbara, Toni, Gringras, Paul and Denton, Jane 2010. The effect of intra-uterine growth on Verbal IQ scores in childhood: a monozygotic twin study. Pediatrics. 126 (5), pp. e1095-e1101.
A Pilot Evaluation of an Online Tool Designed to Aid Development of Basic Laboratory Skills
Booth, P., Kebede-Westhead, Elizabeth, Heaney, Rose and Henderson-Begg, Stephanie K. 2010. A Pilot Evaluation of an Online Tool Designed to Aid Development of Basic Laboratory Skills. Bioscience Education. 15 (c3).
Generating inferences from written and spoken language: a comparison of children with visual impairment and children with sight
Edmonds, C. and Pring, Linda 2006. Generating inferences from written and spoken language: a comparison of children with visual impairment and children with sight. British Journal of Developmental Psychology. 24 (2), pp. 337-351.
Inspection time and cognitive abilities in twins aged 7 to 17 years: age-related changes, heritability and genetic covariance
Edmonds, C., Isaacs, Elizabeth B., Visscher, Peter M., Rogers, Mary, Lanigan, Julie, Singhal, Atul, Lucas, Alan, Gringras, Paul, Denton, Jane and Deary, Ian J. 2008. Inspection time and cognitive abilities in twins aged 7 to 17 years: age-related changes, heritability and genetic covariance. Intelligence. 36 (3), pp. 210-225.
Should children drink more water? The effects of drinking water on cognition in children
Edmonds, C. and Burford, Denise 2009. Should children drink more water? The effects of drinking water on cognition in children. Appetite. 52 (3), pp. 776-779.
Aluminum exposure from parenteral nutrition in preterm infants: bone health at 15-year follow-up
Fewtrell, Mary S., Bishop, Nick J., Edmonds, C., Isaacs, Elizabeth B. and Lucas, Alan 2009. Aluminum exposure from parenteral nutrition in preterm infants: bone health at 15-year follow-up. Pediatrics. 124 (5), pp. 1372-1379.
Does having a drink help you think? 6–7-year-old children show improvements in cognitive performance from baseline to test after having a drink of water
Edmonds, C. and Jeffes, Ben 2009. Does having a drink help you think? 6–7-year-old children show improvements in cognitive performance from baseline to test after having a drink of water. Appetite. 53 (3), pp. 469-472.