Neuroanatomy of verbal working memory as a diagnostic biomarker for depression
Marquand, Andre F., Mourão-Miranda, Janaina, Brammer, Michael J., Cleare, Anthony J. and Fu, C. 2008. Neuroanatomy of verbal working memory as a diagnostic biomarker for depression. NeuroReport. 19 (15), pp. 1507-1511.
|Authors||Marquand, Andre F., Mourão-Miranda, Janaina, Brammer, Michael J., Cleare, Anthony J. and Fu, C.|
The functional neuroanatomy of verbal working memory is a potential diagnostic biomarker for depression. Twenty patients with unipolar depression and 20 healthy controls performed a variable load version (n-back) of the task. Functional MRI data were analysed with support vector machine methods. Diagnostic classification was highest at the mid-level of task difficulty (2-back) (sensitivity 65%, specificity 70%, P<0.009). Significant classification of clinical response (≥50% reduction in clinical symptom ratings) was found at the most difficult level (3-back) (sensitivity 85%, specificity 52%, P<0.003). The functional neuroanatomy of verbal working memory provides a statistically significant but clinically moderate contribution as a diagnostic biomarker for depression, whereas its potential as a neural predictor of clinical response requires further investigation.
|Journal citation||19 (15), pp. 1507-1511|
|Publisher||Lippincott, Williams & Wilkins|
|Digital Object Identifier (DOI)||doi:10.1097/WNR.0b013e328310425e|
|Web address (URL)||https://doi.org/10.1097/WNR.0b013e328310425e|
|08 Oct 2008|
|Publication process dates|
|Deposited||17 Mar 2018|
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