ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Article


Schmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Van Someren, E. J. W., Han, L. K. M., Aftanas, L., Aleman, A., Baune, B. T., Berger, K., Blanken, T. F., Capitão, L., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C., Erwin-Grabner, T., Evans, J., Frodl, T., Fu, C., Godlewska, B., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Groenewold, N. A., Grotegerd, D., Gruber, O., Gutman, B. A., Hall, G. B., Harrison, B. J., Hatton, S. N., Hermesdorf, M., Hickie, I. B., Hilland, E., Irungu, B., Jonassen, R., Kelly, S., Kircher, T., Klimes-Dougan, B., Krug, A., Landrø, N. I., Lagopoulos, J., Leerssen, J., Li, M., Linden, D. E. J., MacMaster, F. P., McIntosh, A. M., Mehler, D. M. A., Nenadić, I., Penninx, B. W. J. H., Portella, M. J., Reneman, L., Rentería, M. E., Sacchet, M. D., Sämann, P. G., Schrantee, A., Sim, K., Soares, J. C., Stein, D. J., Tozzi, L., van Der Wee, N. J. A., van Tol, M., Vermeiren, R., Vives-Gilabert, Y., Walter, H., Walter, M., Whalley, H. C., Wittfeld, K., Whittle, S., Wright, M. J., Yang, T. T., Zarate Jr, C., Thomopoulos, S. I., Jahanshad, N., Thompson, P. M. and Veltman, D. J. 2020. ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing. Translational Psychiatry . 10 (Art. 172). https://doi.org/10.1038/s41398-020-0842-6
AuthorsSchmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Van Someren, E. J. W., Han, L. K. M., Aftanas, L., Aleman, A., Baune, B. T., Berger, K., Blanken, T. F., Capitão, L., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C., Erwin-Grabner, T., Evans, J., Frodl, T., Fu, C., Godlewska, B., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Groenewold, N. A., Grotegerd, D., Gruber, O., Gutman, B. A., Hall, G. B., Harrison, B. J., Hatton, S. N., Hermesdorf, M., Hickie, I. B., Hilland, E., Irungu, B., Jonassen, R., Kelly, S., Kircher, T., Klimes-Dougan, B., Krug, A., Landrø, N. I., Lagopoulos, J., Leerssen, J., Li, M., Linden, D. E. J., MacMaster, F. P., McIntosh, A. M., Mehler, D. M. A., Nenadić, I., Penninx, B. W. J. H., Portella, M. J., Reneman, L., Rentería, M. E., Sacchet, M. D., Sämann, P. G., Schrantee, A., Sim, K., Soares, J. C., Stein, D. J., Tozzi, L., van Der Wee, N. J. A., van Tol, M., Vermeiren, R., Vives-Gilabert, Y., Walter, H., Walter, M., Whalley, H. C., Wittfeld, K., Whittle, S., Wright, M. J., Yang, T. T., Zarate Jr, C., Thomopoulos, S. I., Jahanshad, N., Thompson, P. M. and Veltman, D. J.
Abstract

A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.

JournalTranslational Psychiatry
Journal citation10 (Art. 172)
ISSN2158-3188
Year2020
PublisherSpringer Nature
Publisher's version
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.1038/s41398-020-0842-6
Web address (URL)https://doi.org/10.1038/s41398-020-0842-6
Publication dates
Online29 May 2020
Publication process dates
Accepted07 May 2020
Deposited10 Jun 2020
FunderNational Institutes of Health
UMG Startfoerderung
Bundesministerium fuer Bildung und Forschung
Ministerio de Ciencia e Innovación
Instituto de Salud Carlos III
European Regional Development Fund
National Institute for Health Research Biomedical Research Centre
Canadian Institutes for Health Research
Medical Research Council
Health Research Wales
Deutsche Forschungsgemeinschaft
Gratama Foundation
EU FP7
Wellcome Trust
National Institute of Mental Health
National Healthcare Group
National Health and Medical Research Council of Australia
Biotechnology Research Center
National Alliance for Research on Schizophrenia and Depression, University of Minnesota Graduate School
Minnesota Medical Foundation
Interdisciplinary Center for Clinical Research
ERA-Net Priomedchild
Research Council of Norway
South-Eastern Norway Regional Health Authority
European Research Council
Copyright holder© 2020 The Authors
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Sankar, A., Scott, J., Paszkiewicz, A., Giampietro, V. P., Steiner, H. and Fu, C. 2014. Neural effects of cognitive–behavioural therapy on dysfunctional attitudes in depression. Psychological Medicine. 45 (7), pp. 1425-1433.
Prognostic and Diagnostic Potential of the Structural Neuroanatomy of Depression
Domschke, Katharina, Costafreda, Sergi G., Chu, Carlton, Ashburner, John and Fu, C. 2009. Prognostic and Diagnostic Potential of the Structural Neuroanatomy of Depression. PLOS ONE. 4 (7), p. e6353.
Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
Costafreda, Sergi G, Fu, C., Picchioni, Marco, Toulopoulou, Timothea, McDonald, Colm, Kravariti, Eugenia, Walshe, Muriel, Prata, Diana, Murray, Robin M and McGuire, Philip K 2011. Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder. BMC Psychiatry. 11 (1), p. 18.
Neuroimaging-Based Biomarkers in Psychiatry: Clinical Opportunities of a Paradigm Shift
Fu, C. and Costafreda, Sergi G. 2013. Neuroimaging-Based Biomarkers in Psychiatry: Clinical Opportunities of a Paradigm Shift. Canadian Journal of Psychiatry. 58 (9), pp. 499-508.