ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
Article
Schmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Van Someren, E. J. W., Han, L. K. M., Aftanas, L., Aleman, A., Baune, B. T., Berger, K., Blanken, T. F., Capitão, L., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C., Erwin-Grabner, T., Evans, J., Frodl, T., Fu, C., Godlewska, B., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Groenewold, N. A., Grotegerd, D., Gruber, O., Gutman, B. A., Hall, G. B., Harrison, B. J., Hatton, S. N., Hermesdorf, M., Hickie, I. B., Hilland, E., Irungu, B., Jonassen, R., Kelly, S., Kircher, T., Klimes-Dougan, B., Krug, A., Landrø, N. I., Lagopoulos, J., Leerssen, J., Li, M., Linden, D. E. J., MacMaster, F. P., McIntosh, A. M., Mehler, D. M. A., Nenadić, I., Penninx, B. W. J. H., Portella, M. J., Reneman, L., Rentería, M. E., Sacchet, M. D., Sämann, P. G., Schrantee, A., Sim, K., Soares, J. C., Stein, D. J., Tozzi, L., van Der Wee, N. J. A., van Tol, M., Vermeiren, R., Vives-Gilabert, Y., Walter, H., Walter, M., Whalley, H. C., Wittfeld, K., Whittle, S., Wright, M. J., Yang, T. T., Zarate Jr, C., Thomopoulos, S. I., Jahanshad, N., Thompson, P. M. and Veltman, D. J. 2020. ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing. Translational Psychiatry . 10 (Art. 172). https://doi.org/10.1038/s41398-020-0842-6
Authors | Schmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Van Someren, E. J. W., Han, L. K. M., Aftanas, L., Aleman, A., Baune, B. T., Berger, K., Blanken, T. F., Capitão, L., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C., Erwin-Grabner, T., Evans, J., Frodl, T., Fu, C., Godlewska, B., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Groenewold, N. A., Grotegerd, D., Gruber, O., Gutman, B. A., Hall, G. B., Harrison, B. J., Hatton, S. N., Hermesdorf, M., Hickie, I. B., Hilland, E., Irungu, B., Jonassen, R., Kelly, S., Kircher, T., Klimes-Dougan, B., Krug, A., Landrø, N. I., Lagopoulos, J., Leerssen, J., Li, M., Linden, D. E. J., MacMaster, F. P., McIntosh, A. M., Mehler, D. M. A., Nenadić, I., Penninx, B. W. J. H., Portella, M. J., Reneman, L., Rentería, M. E., Sacchet, M. D., Sämann, P. G., Schrantee, A., Sim, K., Soares, J. C., Stein, D. J., Tozzi, L., van Der Wee, N. J. A., van Tol, M., Vermeiren, R., Vives-Gilabert, Y., Walter, H., Walter, M., Whalley, H. C., Wittfeld, K., Whittle, S., Wright, M. J., Yang, T. T., Zarate Jr, C., Thomopoulos, S. I., Jahanshad, N., Thompson, P. M. and Veltman, D. J. |
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Abstract | A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research. |
Journal | Translational Psychiatry |
Journal citation | 10 (Art. 172) |
ISSN | 2158-3188 |
Year | 2020 |
Publisher | Springer Nature |
Publisher's version | License File Access Level Anyone |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41398-020-0842-6 |
Web address (URL) | https://doi.org/10.1038/s41398-020-0842-6 |
Publication dates | |
Online | 29 May 2020 |
Publication process dates | |
Accepted | 07 May 2020 |
Deposited | 10 Jun 2020 |
Funder | National Institutes of Health |
UMG Startfoerderung | |
Bundesministerium fuer Bildung und Forschung | |
Ministerio de Ciencia e Innovación | |
Instituto de Salud Carlos III | |
European Regional Development Fund | |
National Institute for Health Research Biomedical Research Centre | |
Canadian Institutes for Health Research | |
Medical Research Council | |
Health Research Wales | |
Deutsche Forschungsgemeinschaft | |
Gratama Foundation | |
EU FP7 | |
Wellcome Trust | |
National Institute of Mental Health | |
National Healthcare Group | |
National Health and Medical Research Council of Australia | |
Biotechnology Research Center | |
National Alliance for Research on Schizophrenia and Depression, University of Minnesota Graduate School | |
Minnesota Medical Foundation | |
Interdisciplinary Center for Clinical Research | |
ERA-Net Priomedchild | |
Research Council of Norway | |
South-Eastern Norway Regional Health Authority | |
European Research Council | |
Copyright holder | © 2020 The Authors |
https://repository.uel.ac.uk/item/881q3
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