Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
Article
Pauli, Andreina, Prata, Diana P., Mechelli, Andrea, Picchioni, Marco, Fu, C., Chaddock, Christopher A., Kane, Fergus, Kalidindi, Sridevi, McDonald, Colm, Kravariti, Eugenia, Toulopoulou, Timothea, Bramon, Elvira, Walshe, Muriel, Ehlert, Natascha, Georgiades, Anna, Murray, Robin, Collier, David A. and McGuire, Philip 2012. Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function. Human Brain Mapping. 34 (9), pp. 2244-2258. https://doi.org/10.1002/hbm.22061
Authors | Pauli, Andreina, Prata, Diana P., Mechelli, Andrea, Picchioni, Marco, Fu, C., Chaddock, Christopher A., Kane, Fergus, Kalidindi, Sridevi, McDonald, Colm, Kravariti, Eugenia, Toulopoulou, Timothea, Bramon, Elvira, Walshe, Muriel, Ehlert, Natascha, Georgiades, Anna, Murray, Robin, Collier, David A. and McGuire, Philip |
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Abstract | The genes for the dopamine transporter (DAT) and the D‐Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre‐/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR‐corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. Hum Brain Mapp 34:2244–2258, 2013. © 2012 Wiley Periodicals, Inc. |
Journal | Human Brain Mapping |
Journal citation | 34 (9), pp. 2244-2258 |
ISSN | 10659471 |
Year | 2012 |
Publisher | Wiley |
Digital Object Identifier (DOI) | https://doi.org/10.1002/hbm.22061 |
Web address (URL) | https://doi.org/10.1002/hbm.22061 |
Publication dates | |
Online | 22 Mar 2012 |
Publication process dates | |
Deposited | 17 Mar 2018 |
https://repository.uel.ac.uk/item/85z59
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