The Neuroscience of Sadness: A Multidisciplinary Synthesis and Collaborative Review for the Human Affectome Project
Article
Arias, J. A., Williams, C., Raghvani, R., Aghajani, M., Baez, S., Belzung, C., Booij, L., Busatto, G., Chiarella, J., Fu, C., Ibanez, A., Liddell, B. J., Lowe, L., Penninx, B. W. J. H., Rosa, P. and Kemp, A. H. 2020. The Neuroscience of Sadness: A Multidisciplinary Synthesis and Collaborative Review for the Human Affectome Project. Neuroscience & Biobehavioral Reviews. 111, pp. 199-228. https://doi.org/10.1016/j.neubiorev.2020.01.006
Authors | Arias, J. A., Williams, C., Raghvani, R., Aghajani, M., Baez, S., Belzung, C., Booij, L., Busatto, G., Chiarella, J., Fu, C., Ibanez, A., Liddell, B. J., Lowe, L., Penninx, B. W. J. H., Rosa, P. and Kemp, A. H. |
---|---|
Abstract | Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy. |
Journal | Neuroscience & Biobehavioral Reviews |
Journal citation | 111, pp. 199-228 |
ISSN | 0149-7634 |
Year | 2020 |
Publisher | Elsevier for International Behavioral Neuroscience Society |
Accepted author manuscript | License File Access Level Repository staff only |
Publisher's version | License File Access Level Anyone |
Supplemental file | File Access Level Anyone |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neubiorev.2020.01.006 |
Web address (URL) | https://doi.org/10.1016/j.neubiorev.2020.01.006 |
Publication dates | |
Online | 27 Jan 2020 |
Publication process dates | |
Accepted | 05 Jan 2020 |
Deposited | 21 Jan 2020 |
Funder | National Commission for Scientific and Technological Research (CONICYT) of Chile |
Interamerican Development Bank | |
INECO Foundation | |
Medical Research Council (MRC) | |
Copyright holder | © 2020 The Authors |
https://repository.uel.ac.uk/item/877z6
Download files
Publisher's version
1-s2.0-S0149763418306146-main.pdf | ||
License: CC BY-NC-ND 4.0 | ||
File access level: Anyone |
Supplemental file
Copy of 1-s2.0-S0149763418306146-mmc1.xlsx | ||
File access level: Anyone |
484
total views756
total downloads5
views this month7
downloads this month