Other race effect on amygdala response during affective facial processing in major depression

Article


Sankar, Anjali, Costafreda, Sergi G., Marangell, Lauren B. and Fu, C. 2018. Other race effect on amygdala response during affective facial processing in major depression. Neuroscience Letters. 662, pp. 381-384.
AuthorsSankar, Anjali, Costafreda, Sergi G., Marangell, Lauren B. and Fu, C.
Abstract

Objective: The other race effect, also known as own race bias, refers to the enhanced ability to recognize faces belonging to one’s own race relative to faces from another race. The other race effect is associated with increased amygdala response in healthy individuals. The amygdala is a key node in emotion processing which shows impaired functioning in depression and has been proposed to be a marker of depressive state. We investigated the impact of the other race effect on amygdala responses in depression.
Methods: Participants were 30 individuals with major depression (mean age39.4 years) and 23 healthy individuals (mean age: 38.8 years) recruited from the community. Participants were Asian, Black/African American and Caucasian. During a functional MRI scan, participants viewed Caucasian faces which displayed a range of sad expressions. A region of interest analysis of left and right amygdala responses was performed.
Results: Increased bilateral amygdala responses were observed in response to the Caucasian face stimuli in participants who were Asian or Black/African American as compared to Caucasian participants in both healthy individuals and individuals with major depression. There was no significant group by race interaction effect.
Conclusions: Increased amygdala responses associated with the other race effect were evident in both individuals with major depression and in healthy participants. Increased amygdala responses with the other race effect is a potential confound of the neural correlates of facial processing in healthy participants and in mental health disorders. The implications of the other race effect on impairments in interpersonal functioning in depression require further investigation.

JournalNeuroscience Letters
Journal citation662, pp. 381-384
ISSN0304-3940
Year2018
PublisherElsevier
Accepted author manuscript
License
CC BY-NC-ND
Digital Object Identifier (DOI)doi:10.1016/j.neulet.2017.10.043
Web address (URL)https://doi.org/10.1016/j.neulet.2017.10.043
Publication dates
Print01 Jan 2018
Online25 Oct 2017
Publication process dates
Deposited06 Nov 2017
Accepted20 Oct 2017
Accepted31 Oct 2017
Copyright information© 2017 Elsevier
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