Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder
Article
Legge, R. M., Sendi, S., Cole, J. H., Cohen-Woods, S., Costafreda, S. G., Simmons, A., Farmer, A. E., Aitchison, K. J., McGuffin, P. and Fu, C. 2015. Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. The British Journal of Psychiatry. 206 (5), pp. 379-384.
Authors | Legge, R. M., Sendi, S., Cole, J. H., Cohen-Woods, S., Costafreda, S. G., Simmons, A., Farmer, A. E., Aitchison, K. J., McGuffin, P. and Fu, C. |
---|---|
Abstract | Background: Brain derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to development of depression (MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD Aims: To investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions. Method: MRI scans were acquired in 79 MDD (mean age 49 years) and 74 healthy volunteers (HV) (mean 50 years). Effects on surface area and cortical thickness were Results: Met allele carriers showed reduced caudal middle frontal thickness in both MDD and HV. Significant interaction effects were found in the anterior cingulate and rostral middle frontal regions in which Met MDD carriers showed the greatest reduction in surface area. Conclusions: Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression. |
Journal | The British Journal of Psychiatry |
Journal citation | 206 (5), pp. 379-384 |
ISSN | 0007-1250 |
Year | 2015 |
Publisher | Royal College of Psychiatrists |
Accepted author manuscript | License CC BY |
Web address (URL) | http://dx.doi.org/10.1192/bjp.bp.113.143529 |
Publication dates | |
05 Mar 2015 | |
Publication process dates | |
Deposited | 15 Jun 2015 |
Accepted | 24 Sep 2014 |
Funder | GlaxoSmithKline UK |
National Institute of Health Research Biomedical Research Centre for Mental Health | |
Kings College London, Institute of Psychiatry | |
Brain and Behaviour Research Foundation | |
Sixth Framework Programme | |
Medical Research Council | |
Medical Research Council | |
Wellcome Trust | |
Copyright information | This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org |
https://repository.uel.ac.uk/item/856y8
Download files
208
total views203
total downloads0
views this month0
downloads this month