Prospects of Pharmacological Interventions to Organismal Aging

Article

Hillson, Olivia, Gonzalez, Suam and Rallis, C. 2018. Prospects of Pharmacological Interventions to Organismal Aging. Biomolecular Concepts. 9 (1), pp. 200-215. https://doi.org/10.1515/bmc-2018-0018
AuthorsHillson, Olivia, Gonzalez, Suam and Rallis, C.
Abstract

Intense research in the areas of cellular and organismal aging using diverse laboratory model systems has enriched our knowledge in the processes and the signalling pathways involved in normal and pathological conditions. The field finds itself in a position to take decisive steps towards clinical applications and interventions not only for targeted age-related diseases such as cardiovascular conditions and neurodegeneration but also for the modulation of health span and lifespan of a whole organism. Beyond nutritional interventions such as dietary restriction without malnutrition and various regimes of intermittent fasting, accumulating evidence provides promise for pharmacological interventions. The latter, mimic caloric or dietary restriction, tune cellular and organismal stress responses, affect the metabolism of microbiome with subsequent effects on the host or modulate repair pathways, among others. In this mini review, we summarise some of the evidence on drugs that can alter organismal lifespan and the prospects they might offer for promoting healthspan and delaying age-related diseases.

JournalBiomolecular Concepts
Journal citation9 (1), pp. 200-215
ISSN1868-5021
Year2018
PublisherDe Gruyter
Publisher's version
License
Digital Object Identifier (DOI)https://doi.org/10.1515/bmc-2018-0018
Web address (URL)https://doi.org/10.1515/bmc-2018-0018
Publication dates
Online31 Dec 2018
Publication process dates
Deposited11 Feb 2019
Accepted04 Dec 2018
Accepted04 Dec 2018
FunderUniversity of East London
University of East London
Copyright information© 2018 The authors
LicenseCC BY-NC-ND 4.0
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