Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo

Article

Rallis, C. 2005. Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo. Development. 132 (8), pp. 1961-1970. https://doi.org/10.1242/dev.01787
AuthorsRallis, C.
Abstract

The limbs of the vertebrate embryo form at precise
locations along the body and these positions are fixed across
different species. The mechanisms that control this process
are not understood. Ectopic expression of Tbx3, a
transcriptional repressor that belongs to the Tbx2/3/4/5
subfamily of T-box transcriptional regulators, in the
forelimb results in a rostral shift in the position of the limb
along the main body axis. By contrast, a transcriptional
activator form of Tbx3 shifts the limb to more caudal
locations. We also show that dHand and Gli3, genes
previously implicated in anteroposterior pre-patterning of
the limb-forming region, are also involved in refining the
position of the limbs. Our data suggest a new role for Tbx3
in positioning the limb along the main body axis through a
genetic interplay between dHand and Gli3.

JournalDevelopment
Journal citation132 (8), pp. 1961-1970
ISSN0950-1991
Year2005
PublisherThe Company of Biologists Ltd
Publisher's version
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Digital Object Identifier (DOI)https://doi.org/10.1242/dev.01787
Web address (URL)https://doi.org/10.1242/dev.01787
Publication dates
Online24 Mar 2005
Publication process dates
Deposited13 Feb 2018
Accepted14 Feb 2005
Accepted14 Feb 2005
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