The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth

Article

Gonzalez, Suam and Rallis, C. 2017. The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth. Frontiers in Cell and Developmental Biology. 5. https://doi.org/10.3389/fcell.2017.00061
AuthorsGonzalez, Suam and Rallis, C.
Abstract

Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR) signaling pathway regulates cellular metabolic status and growth in response to numerous inputs. Timing and duration of TOR pathway activity is pivotal for both cell mass built up as well as cell cycle progression and is controlled and fine-tuned by the abundance and quality of nutrients, hormonal signals, growth factors, stress, and oxygen. TOR kinases function within two functionally and structurally discrete multiprotein complexes, TORC1 and TORC2, that are implicated in temporal and spatial control of cell size and growth respectively; however, recent data indicate that such functional distinctions are much more complex. Here, we briefly review roles of the two complexes in cellular growth and cytoarchitecture in various experimental model systems.

JournalFrontiers in Cell and Developmental Biology
Journal citation5
ISSN2296-634X
Year2017
PublisherFrontiers Media
Publisher's version
License
CC BY
Digital Object Identifier (DOI)https://doi.org/10.3389/fcell.2017.00061
Web address (URL)https://doi.org/10.3389/fcell.2017.00061
Publication dates
Print07 Jun 2017
Publication process dates
Deposited08 Jun 2017
Accepted27 May 2017
FunderUniversity of East London (UEL)
University of East London (UEL)
University of East London
University of East London
Copyright information© 2017 Gonzalez and Rallis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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