The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth
Article
Gonzalez, Suam and Rallis, C. 2017. The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth. Frontiers in Cell and Developmental Biology. 5. https://doi.org/10.3389/fcell.2017.00061
Authors | Gonzalez, Suam and Rallis, C. |
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Abstract | Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR) signaling pathway regulates cellular metabolic status and growth in response to numerous inputs. Timing and duration of TOR pathway activity is pivotal for both cell mass built up as well as cell cycle progression and is controlled and fine-tuned by the abundance and quality of nutrients, hormonal signals, growth factors, stress, and oxygen. TOR kinases function within two functionally and structurally discrete multiprotein complexes, TORC1 and TORC2, that are implicated in temporal and spatial control of cell size and growth respectively; however, recent data indicate that such functional distinctions are much more complex. Here, we briefly review roles of the two complexes in cellular growth and cytoarchitecture in various experimental model systems. |
Journal | Frontiers in Cell and Developmental Biology |
Journal citation | 5 |
ISSN | 2296-634X |
Year | 2017 |
Publisher | Frontiers Media |
Publisher's version | License CC BY |
Digital Object Identifier (DOI) | https://doi.org/10.3389/fcell.2017.00061 |
Web address (URL) | https://doi.org/10.3389/fcell.2017.00061 |
Publication dates | |
07 Jun 2017 | |
Publication process dates | |
Deposited | 08 Jun 2017 |
Accepted | 27 May 2017 |
Funder | University of East London (UEL) |
University of East London (UEL) | |
University of East London | |
University of East London | |
Copyright information | © 2017 Gonzalez and Rallis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
https://repository.uel.ac.uk/item/84v61
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