Urban Leptospirosis in Africa: A Cross-Sectional Survey of Leptospira Infection in Rodents in the Kibera Urban Settlement, Nairobi, Kenya
Halliday, J. E. B., Knobel, D. L., Allan, K. J., de C. Bronsvoort, B. M., Handel, I., Agwanda, B., Cutler, S., Olack, B., Ahmed, A., Hartskeerl, R. A., Njenga, M. K., Cleaveland, S. and Breiman, R. F. 2013. Urban Leptospirosis in Africa: A Cross-Sectional Survey of Leptospira Infection in Rodents in the Kibera Urban Settlement, Nairobi, Kenya. American Journal of Tropical Medicine and Hygiene. 89 (6), pp. 1095-1102.
|Authors||Halliday, J. E. B., Knobel, D. L., Allan, K. J., de C. Bronsvoort, B. M., Handel, I., Agwanda, B., Cutler, S., Olack, B., Ahmed, A., Hartskeerl, R. A., Njenga, M. K., Cleaveland, S. and Breiman, R. F.|
Leptospirosis is a widespread but under-reported cause of morbidity and mortality. Global re-emergence of leptospirosis has been associated with the growth of informal urban settlements in which rodents are thought to be important reservoir hosts. Understanding the multi-host epidemiology of leptospirosis is essential to control and prevent disease. A cross-sectional survey of rodents in the Kibera settlement in Nairobi, Kenya was conducted in September–October 2008 to demonstrate the presence of pathogenic leptospires. A real-time quantitative polymerase chain reaction showed that 41 (18.3%) of 224 rodents carried pathogenic leptospires in their kidneys, and sequence data identified Leptospira interrogans and L. kirschneri in this population. Rodents of the genus Mus (37 of 185) were significantly more likely to be positive than those of the genus Rattus (4 of 39; odds ratio = 15.03). Questionnaire data showed frequent contact between humans and rodents in Kibera. This study emphasizes the need to quantify the public health impacts of this neglected disease at this and other urban sites in Africa.
|Journal||American Journal of Tropical Medicine and Hygiene|
|Journal citation||89 (6), pp. 1095-1102|
|Publisher||American Society of Tropical Medicine and Health|
|Web address (URL)||http://dx.doi.org/10.4269/ajtmh.13-0415|
|30 Sep 2013|
|Publication process dates|
|Deposited||13 Jan 2014|
|Copyright information||Copyright © 2013 by The American Society of Tropical Medicine and Hygiene. This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.|
1views this month
7downloads this month