Positron emission tomography PET/CT harmonisation study of different clinical PET/CT scanners using commercially available software

Article


Lowe, G., Spottiswoode, B., Declerck, J., Sullivan,, K., Sharif, S., Wong, W. and Sanghera, B. 2020. Positron emission tomography PET/CT harmonisation study of different clinical PET/CT scanners using commercially available software. BJR Open. 2 (Art. 20190035).
AuthorsLowe, G., Spottiswoode, B., Declerck, J., Sullivan,, K., Sharif, S., Wong, W. and Sanghera, B.
Abstract

Objectives: Harmonisation is the process whereby
standardised uptake values from different scanners can
be made comparable. This PET/CT pilot study aimed to
evaluate the effectiveness of harmonisation of a modern
scanner with image reconstruction incorporating resolution recovery (RR) with another vendor older scanner operated in two-dimensional (2D) mode, and for both against a European standard (EARL). The vendor-proprietary software EQ•PET was used, which achieves harmonisation with a Gaussian smoothing. A substudy investigated effect of RR on harmonisation.
Methods: Phantom studies on each scanner were
performed to optimise the smoothing parameters
required to achieve successful harmonisation. 80
patients were retrospectively selected; half were imaged
on each scanner. As proof of principle, a cohort of 10
patients was selected from the modern scanner subjects
to study the effects of RR on harmonisation.
Results: Before harmonisation, the modern scanner
without RR adhered to EARL specification. Using the
phantom data, filters were derived for optimal harmonisation between scanners and with and without RR as
applicable, to the EARL standard. The 80-patient
cohort did not reveal any statistically significant differences. In the 10-patient cohort SUVmax for RR > no RR irrespective of harmonisation but differences lacked statistical significance (one-way ANOVA F(3.36) = 0.37, p = 0.78). Bland-Altman analysis showed that harmonisation reduced the SUVmax ratio between RR and no RR to 1.07 (95% CI 0.96–1.18) with no outliers.
Conclusions: EQ•PET successfully enabled harmonisation
between modern and older scanners and against
the EARL standard. Harmonisation reduces SUVmax and
dependence on the use of RR in the modern scanner.
Advances in knowledge: EQ•PET is feasible to harmonise
different PET/CT scanners and reduces the effect of
RR on SUVmax.

JournalBJR Open
Journal citation2 (Art. 20190035)
ISSN2513-9878
Year2020
PublisherBritish Institute of Radiology
Publisher's version
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File Access Level
Anyone
Digital Object Identifier (DOI)doi:10.1259/bjro.20190035
Web address (URL)https://doi.org/10.1259/bjro.20190035
Publication dates
Online02 Jun 2020
Publication process dates
Accepted04 May 2020
Deposited08 Jun 2020
Copyright holder© 2020 The Authors
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